握力与海马体积和大脑白质高信号在重度抑郁症和健康对照中的相关性：英国生物银行研究。
Handgrip Strength Is Associated With Hippocampal Volume and White Matter Hyperintensities in Major Depression and Healthy Controls: A UK Biobank Study.
机构信息
From the Department of Zoology, Edward Grey Institute (J.A. Firth), and Merton College (J.A. Firth), University of Oxford, Oxford; The Cambridge Centre for Sport and Exercise Sciences, Department of Life Sciences (Smith), Anglia Ruskin University, Cambridge, United Kingdom; NICM Health Research Institute, Western Sydney University (Sarris, J. Firth), Westmead; Department of Psychiatry (Sarris), University of Melbourne, The Melbourne Clinic, Melbourne, Australia; Department of Rehabilitation Sciences (Vancampfort), KU Leuven, Leuven, Belgium; Department of Sports Methods and Techniques, Federal University of Santa Maria (Schuch), Santa Maria, Brazil; Centre for Addiction and Mental Health (Carvalho), Toronto, Ontario, Canada; Department of Psychiatry (Carvalho), University of Toronto, Toronto, Ontario, Canada; Department of Neurosciences (Solmi), University of Padova; Local Health Unit 17 ULSS 17, Mental Health Department (Solmi), Padova, Italy; Physiotherapy Department (Yung, Stubbs), South London and Maudsley NHS Foundation Trust; Department of Psychological Medicine, Institute of Psychiatry (Yung, Stubbs), Psychology and Neuroscience, King's College London, London; Division of Psychology and Mental Health, Faculty of Biology, Medicine and Health (J. Firth), University of Manchester, Manchester, United Kingdom; and Centre for Youth Mental Health, University of Melbourne (J. Firth), Melbourne, Australia.
出版信息
Psychosom Med. 2020 Jan;82(1):39-46. doi: 10.1097/PSY.0000000000000753.
OBJECTIVE
Emerging evidence suggests that handgrip strength (a proxy for muscular fitness) is associated with better cognitive performance in people with major depressive disorder (MDD). The underlying processes are unclear, although hippocampal volume (HCV) reductions and white matter hyperintensities (WMHs) have been implicated. Therefore, we investigated the associations between handgrip strength and various brain region volumes and WMHs in MDD and healthy controls (HCs).
METHODS
This study is a cross-sectional analysis of handgrip strength and neuroimaging data from the UK Biobank. Generalized linear models were used to assess the relationship between grip strength and gray matter, white matter, total brain volume, left and right hippocampus volume, and WMHs in MDD and HCs, adjusting for age, sex, education, and body weight.
RESULTS
The sample included 527 people with MDD (54.3 ± 7.3 years, 37.2% male) and 1764 HCs (56.6 ± 7.2 years, 53% male). In MDD, stronger handgrip was significantly associated with increased left (coefficient ± SE = 108.1 ± 27.6, t = 3.92) and right (76.8 ± 30.4, t = 2.53) HCV. In HCs, only right HCV related to handgrip strength (44.8 ± 18.1, t = 2.47). Interaction analyses found stronger associations between grip strength and HCV in MDD compared with HCs, for both hippocampal regions. Stronger handgrip was associated with reduced WMHs in people with MDD (-0.24 ± 0.07, t = -3.24) and HCs (-0.11 ± 0.04, t = -2.47). Maximal handgrip strength was not associated with gray matter, white matter, or total brain volumes in either group.
CONCLUSIONS
Stronger grip strength is associated with greater left and right HCV and reduced WMHs in MDD. Future research should investigate directionality and consider if interventions targeting strength/muscular fitness can improve brain health and reduce the neurocognitive abnormalities associated with MDD.
目的
越来越多的证据表明，握力（肌肉健康的代表）与重度抑郁症（MDD）患者的认知表现更好有关。其潜在机制尚不清楚，尽管海马体体积（HCV）减少和脑白质高信号（WMHs）与 MDD 有关。因此，我们研究了 MDD 患者和健康对照者（HCs）的握力与各种脑区体积和 WMHs 之间的关联。
方法
这是一项来自英国生物银行的握力和神经影像学数据的横断面分析。使用广义线性模型来评估握力与灰质、白质、全脑体积、左、右海马体体积以及 MDD 和 HCs 中的 WMHs 之间的关系，调整年龄、性别、教育程度和体重。
结果
该样本包括 527 名 MDD 患者（54.3±7.3 岁，37.2%为男性）和 1764 名 HCs（56.6±7.2 岁，53%为男性）。在 MDD 患者中，握力越强，左（系数±SE=108.1±27.6，t=3.92）和右（76.8±30.4，t=2.53）HCV 越大。在 HCs 中，只有右 HCV 与握力相关（44.8±18.1，t=2.47）。交互分析发现，与 HCs 相比，MDD 患者的握力与 HCV 之间的关联更强，左右侧海马体均如此。握力越强，MDD 患者（-0.24±0.07，t=-3.24）和 HCs（-0.11±0.04，t=-2.47）的 WMHs 越少。在两组中，最大握力均与灰质、白质或全脑体积无关。
结论
在 MDD 患者中，较强的握力与左右 HCV 较大和 WMHs 减少有关。未来的研究应该探讨其方向性，并考虑针对力量/肌肉健康的干预措施是否可以改善大脑健康并减少与 MDD 相关的神经认知异常。
Zotero 插件