两种人类单核细胞抗原的遗传学

Genetics of two human monocyte antigens.

作者信息

Jager M J, Claas F H, Schot J D, Gratama J W, de Lange G, van Rood J J

机构信息

Department of Immunohaematology and Blood Bank, University Hospital, Leiden, The Netherlands.

出版信息

Hum Immunol. 1988 Jul;22(3):163-70. doi: 10.1016/0198-8859(88)90025-0.

DOI:10.1016/0198-8859(88)90025-0

PMID:3170285

Abstract

HMA-1 and HMA-2 are two serologically defined alloantigens that are present on human monocytes and granulocytes. Previous panel studies suggested that these two antigens comprise a diallelic system. We therefore performed segregation studies on 10 randomly chosen families and on 22 nucleus families belonging to one large pedigree. All individuals were either positive for HMA-1, HMA-2, or both. Segregation of HMA-1 showed autosomal inheritance with complete penetrance. The cytotoxicity negative, absorption positive (CYNAP) phenomenon sometimes occurred for HMA-2, and because absorptions for HMA-2 could not be performed on all cells, linkage studies were only performed for HMA-1. No linkage of HMA-1 with HLA, immunoglobulin allotypes, granulocyte antigens, or any of the erythrocyte blood groups tested was observed.

摘要

HMA - 1和HMA - 2是两种血清学定义的同种异体抗原，存在于人类单核细胞和粒细胞上。先前的分组研究表明，这两种抗原构成一个双等位基因系统。因此，我们对随机选择的10个家庭以及属于一个大型谱系的22个核心家庭进行了分离研究。所有个体要么HMA - 1呈阳性，要么HMA - 2呈阳性，要么两者均呈阳性。HMA - 1的分离显示出常染色体显性遗传且具有完全外显率。HMA - 2有时会出现细胞毒性阴性、吸收阳性（CYNAP）现象，并且由于无法对所有细胞进行HMA - 2的吸收试验，所以仅对HMA - 1进行了连锁研究。未观察到HMA - 1与HLA、免疫球蛋白同种异型、粒细胞抗原或所检测的任何红细胞血型之间存在连锁关系。