犬单核细胞相关抗原的识别。

Recognition of monocyte-associated antigens in the dog.

作者信息

Krumbacher K, Happel M, Grosse-Wilde H

机构信息

Institute of Immunogenetics, University Hospital Essen, Fed. Rep. Germany.

出版信息

Tissue Antigens. 1991 Jan;37(1):21-5. doi: 10.1111/j.1399-0039.1991.tb01839.x.

DOI:10.1111/j.1399-0039.1991.tb01839.x

PMID:2063395

Abstract

Canine pregnant sera were investigated for monocyte-specific cytotoxic antibodies against a cell panel from 50 unrelated dogs. Contaminating DLA and DLB reactivity was removed by absorption on a random pool of purified lymphocytes. Two monocyte-associated antigens were recognized by two independent clusters of antisera; the existence of further antigens is suggested. In preliminary segregation studies, the inheritance of these determinants in linkage with DLA could not be observed.

摘要

对犬类妊娠血清进行了研究，以检测其针对来自50只无关犬的细胞系的单核细胞特异性细胞毒性抗体。通过在随机纯化淋巴细胞库上吸附，去除了污染的DLA和DLB反应性。两个独立的抗血清簇识别出两种单核细胞相关抗原；提示可能存在其他抗原。在初步的分离研究中，未观察到这些决定簇与DLA连锁的遗传情况。