人类单核细胞上的两种同种异体抗原：一个双等位基因系统？

Two alloantigens on human monocytes: a diallelic system?

作者信息

Jager M J, Claas F H, D'Amaro J, Baldwin W M, van Rood J J

出版信息

Hum Immunol. 1987 Jul;19(3):215-24. doi: 10.1016/0198-8859(87)90116-9.

Abstract

A positive monocyte crossmatch and therefore anti-monocyte antibodies are negative factors in bone marrow and renal transplantation. When the monocyte antigens themselves can be recognized, matching for the antigens involved here may become a possibility. In order to find useful anti-monocyte sera as typing reagents, human sera were screened against panel cells. Several monocyte specific sera were obtained. These sera recognized two monocyte antigens, HMA-1 and HMA-2. No similarity with any of the HLA antigens was observed. Every individual tested was positive for at least one of these two monocyte antigens, suggesting that HMA-1 and HMA-2 constitute a diallelic system.

摘要

单核细胞交叉配型阳性，因此抗单核细胞抗体在骨髓和肾移植中是负面因素。当单核细胞抗原本身能够被识别时，针对此处所涉及抗原进行配型就有可能实现。为了找到有用的抗单核细胞血清作为分型试剂，用人类血清对一组细胞进行筛选。获得了几种单核细胞特异性血清。这些血清识别两种单核细胞抗原，即HMA - 1和HMA - 2。未观察到与任何HLA抗原存在相似性。每个受检个体至少对这两种单核细胞抗原中的一种呈阳性反应，这表明HMA - 1和HMA - 2构成一个双等位基因系统。