Frontier Institute of Science and Technology , Xi'an Jiaotong University , Xi'an 710000 , China.
Department of Biologic and Materials Science , University of Michigan , Ann Arbor , Michigan 48109 , United States.
ACS Nano. 2020 Jan 28;14(1):442-453. doi: 10.1021/acsnano.9b06145. Epub 2019 Dec 24.
The simultaneous therapy of tumors and bone defects resulting from tumor surgery is still a challenge in clinical orthopedics. Few nanomaterial systems simultaneously possess multifunctional capacities, including biodegradability, tumor treatment, and enhanced bone regeneration. Herein, we designed a biodegradable monodispersed bioactive glass nanoparticle (BGN) platform with multifunctional properties for enhanced colon cancer photothermo-chemotherapy and bone repair. The mussel-inspired surface assembly with BGN was established as a stable NIR-excited photothermal nanoplatform (BGN@PDA) for ablating tumors. BGN@PDA shows an ultrahigh anticancer drug (DOX) loading with on-demand (pH/NIR-responsive) drug release behavior and antibacterial activity for enhanced tumor chemotherapy (BGN@PDA-DOX). The growth of colon cancer cells (Hct116 cells) and cervical cancer cells (HeLa cells) was significantly inhibited , and superior local anticancer efficacy could be achieved by synergic chemo-photothermal therapy . BGN@PDA underwent a gradual degradation during 60 days and showed negligible toxic side effects. Meanwhile, BGN@PDA could positively induce the osteogenesis of osteoblasts and possess excellent bone repair ability in rat cranial defects. This work presents a distinctive strategy to design a bioactive multifunctional nanoplatform for treating tumor disease-resulted bone tissue regeneration.
同时治疗肿瘤和肿瘤手术引起的骨缺损仍然是临床骨科的一个挑战。很少有纳米材料系统同时具有多种功能，包括生物降解性、肿瘤治疗和增强骨再生。本文设计了一种具有多功能特性的可生物降解的单分散生物活性玻璃纳米颗粒（BGN）平台，用于增强结肠癌光热化疗和骨修复。基于贻贝启发的表面组装方法，建立了一种稳定的近红外激发光热纳米平台（BGN@PDA），用于消融肿瘤。BGN@PDA 具有超高的抗癌药物（DOX）负载量，具有按需（pH/NIR 响应）药物释放行为和抗菌活性，可增强肿瘤化疗（BGN@PDA-DOX）。BGN@PDA-DOX 可显著抑制结肠癌细胞（Hct116 细胞）和宫颈癌细胞（HeLa 细胞）的生长，并通过协同化学-光热疗法实现更好的局部抗癌效果。BGN@PDA 在 60 天内逐渐降解，几乎没有毒副作用。同时，BGN@PDA 可以促进成骨细胞的成骨作用，并在大鼠颅缺损中具有优异的骨修复能力。这项工作提出了一种独特的策略，用于设计用于治疗肿瘤疾病引起的骨组织再生的生物活性多功能纳米平台。
