Yang Yulian, Qiu Yonghao, Lin Cai, Chen Xiaofeng, Zhao Fujian
Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou 510280, PR China.
Department of Burn, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China.
Theranostics. 2025 Jan 2;15(5):1760-1786. doi: 10.7150/thno.104944. eCollection 2025.
Smart biomaterials with active environmental responsiveness have attracted widespread attention in recent years. Previous studies on bioactive glass (BG) have mainly focused on the property of bioactivity, while little attention has been paid to the property of smart response of BG. Herein, we propose the concept of Smart Bioactive Glass Composites (SBGC) which are capable of actively responding to the endogenous disease microenvironment or exogenous physical stimuli, thereby enabling active treatment of tissue defect sites and ultimately promoting tissue regeneration. In this review, the response characteristics of SBGC to different internal and external environments are described. Subsequently, the applications of SBGC in complex tissue defect repair of tumors, infections, and diabetes are reviewed. By deeply analyzing the recent progress of SBGC in different fields, this review will point out the direction for the research of next-generation BG.
近年来，具有主动环境响应性的智能生物材料受到了广泛关注。以往对生物活性玻璃（BG）的研究主要集中在生物活性特性上，而对BG的智能响应特性关注较少。在此，我们提出了智能生物活性玻璃复合材料（SBGC）的概念，它能够主动响应内源性疾病微环境或外源性物理刺激，从而实现对组织缺损部位的主动治疗并最终促进组织再生。在这篇综述中，描述了SBGC对不同内部和外部环境的响应特性。随后，综述了SBGC在肿瘤、感染和糖尿病等复杂组织缺损修复中的应用。通过深入分析SBGC在不同领域的最新进展，本综述将为下一代BG的研究指明方向。
