George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA.
Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA.
Spine (Phila Pa 1976). 2020 Apr 15;45(8):E417-E424. doi: 10.1097/BRS.0000000000003303.
An in vivo study examining the functional osseointegration of smooth, rough, and porous surface topographies presenting polyether-ether-ketone (PEEK) or titanium surface chemistry.
To investigate the effects of surface topography and surface chemistry on implant osseointegration.
Interbody fusion devices have been used for decades to facilitate fusion across the disc space, yet debate continues over their optimal surface topography and chemistry. Though both factors influence osseointegration, the relative effects of each are not fully understood.
Smooth, rough, and porous implants presenting either a PEEK or titanium surface chemistry were implanted into the proximal tibial metaphyses of 36 skeletally mature male Sprague Dawley rats. At 8 weeks, animals were euthanized and bone-implant interfaces were subjected to micro-computed tomography analysis (n = 12), histology (n = 4), and biomechanical pullout testing (n = 8) to assess functional osseointegration and implant fixation.
Micro-computed tomography analysis demonstrated that bone ingrowth was 38.9 ± 2.8% for porous PEEK and 30.7 ± 3.3% for porous titanium (P = 0.07). No differences in fixation strength were detected between porous PEEK and porous titanium despite titanium surfaces exhibiting an overall increase in bone-implant contact compared with PEEK (P < 0.01). Porous surfaces exhibited increased fixation strength compared with smooth and rough surfaces regardless of surface chemistry (P < 0.05). Across all groups both surface topography and chemistry had a significant overall effect on fixation strength (P < 0.05), but topography accounted for 65.3% of the total variance (ω = 0.65), whereas surface chemistry accounted for 5.9% (ω = 0.06).
The effect of surface topography (specifically porosity) dominated the effect of surface chemistry in this study and could lead to further improvements in orthopedic device design. The poor osseointegration of existing smooth PEEK implants may be linked more to their smooth surface topography rather than their material composition.
N/A.
一项体内研究，旨在考察呈现聚醚醚酮（PEEK）或钛表面化学特性的光滑、粗糙和多孔表面形貌对种植体骨整合功能的影响。
研究表面形貌和表面化学对种植体骨整合的影响。
几十年来，椎间融合器一直被用于促进椎间盘间隙的融合，但关于其最佳表面形貌和化学特性仍存在争议。虽然这两个因素都影响骨整合，但它们各自的相对影响尚不完全清楚。
将呈现 PEEK 或钛表面化学特性的光滑、粗糙和多孔种植体植入 36 只成年雄性 Sprague Dawley 大鼠的胫骨近端干骺端。8 周后，处死动物，对骨-种植体界面进行微计算机断层扫描分析（n = 12）、组织学分析（n = 4）和生物力学拔出试验（n = 8），以评估功能性骨整合和种植体固定。
微计算机断层扫描分析显示，多孔 PEEK 的骨内生长率为 38.9 ± 2.8%，多孔钛为 30.7 ± 3.3%（P = 0.07）。尽管钛表面的骨-种植体接触总体上高于 PEEK，但多孔 PEEK 和多孔钛之间的固定强度没有差异（P < 0.01）。与光滑和粗糙表面相比，多孔表面的固定强度增加，而与表面化学无关（P < 0.05）。在所有组中，表面形貌和化学都对固定强度有显著的总体影响（P < 0.05），但形貌占总方差的 65.3%（ω = 0.65），而化学占 5.9%（ω = 0.06）。
在本研究中，表面形貌（特别是多孔性）的影响超过了表面化学的影响，这可能会进一步改进骨科器械的设计。现有光滑 PEEK 种植体的骨整合不良可能与其光滑的表面形貌有关，而不是其材料组成。
无。
