Department of Medical Laboratory, College of Medicine and Health Science, Adigrat University, P.O. Box, 50, Adigrat, Ethiopia.
Department of Microbiology and Immunology, Institute of Biomedical Sciences, College of Health Science, Mekelle University, P.O. Box, 1870, Mekelle, Ethiopia.
BMC Infect Dis. 2019 Nov 8;19(1):950. doi: 10.1186/s12879-019-4610-2.
Bacterial infection of the urinary tract is among the common reasons for seeking medical attention in the community. Rapidly increasing antibiotic resistance of uropathogens is resulting in limited treatment options. Therefore, knowledge of the current uropathogens and their antibiotic susceptibility is important for better treatment of urinary tract infection.
A cross-sectional study design was conducted from February to September thirty, 2017 among students who came to Mekelle University student's clinics with symptomatic urinary tract infection during the study period.. Mid-stream urine specimens were collected from 341individuals with suspected urinary tract infection for bacteriological identification and antimicrobial susceptibility testing. Data on socio-demographic, clinical and risk factors were also collected using a structured questionnaire.
Among the 341 study participants, 72(21.1%) showed significant bacteriuria. Escherichia coli (48.6%), Coagulase-negative staphylococci (23%), Staphylococcus aureus (13.5%), and Klebsiella spp. (8.1%) were common bacterial isolates. Resistance to ampicillin (81-100%), amoxicillin/clavulanic acid (77-93.6%), co- trimoxazole (55 72.3%), nalidixic acid (57.4%) and tetracycline (46-55.5%) was seen by most isolates. Multidrug resistance was observed in 73% of the bacterial isolates, and 25.5% of the Gram-negative isolates were extended-spectrum beta-lactamase producers. Being female, a history of urinary tract infection, a history of catheterization and frequent sexual activity were found to be statistically associated with urinary tract infection.
Urinary tract infection is a problem among university students with a prevalence of 21.1%. All isolates have developed resistance to most of the commonly used antibiotics. Therefore, health education on the transmission and causes of urinary tract infection are recommended for the students.
尿路感染是社区就诊的常见原因之一。尿路病原体的抗生素耐药性迅速增加，导致治疗选择有限。因此，了解当前尿路病原体及其抗生素敏感性对于更好地治疗尿路感染非常重要。
2017 年 2 月至 9 月 30 日，在研究期间，对因有症状性尿路感染而前往梅克莱大学学生诊所就诊的学生进行了一项横断面研究设计。从中段尿标本中采集了 341 名疑似尿路感染患者的标本，进行细菌学鉴定和抗菌药物敏感性试验。还使用结构化问卷收集了社会人口统计学、临床和危险因素的数据。
在 341 名研究参与者中，72 人（21.1%）表现出明显的菌尿。大肠埃希菌（48.6%）、凝固酶阴性葡萄球菌（23%）、金黄色葡萄球菌（13.5%）和克雷伯氏菌属（8.1%）是常见的细菌分离株。大多数分离株对氨苄西林（81-100%）、阿莫西林/克拉维酸（77-93.6%）、复方磺胺甲噁唑（55-72.3%）、萘啶酸（57.4%）和四环素（46-55.5%）耐药。73%的细菌分离株表现出多药耐药性，25.5%的革兰氏阴性分离株为产超广谱β-内酰胺酶。女性、尿路感染史、导尿史和频繁的性行为被发现与尿路感染有统计学关联。
尿路感染是大学生中存在的一个问题，患病率为 21.1%。所有分离株对大多数常用抗生素都产生了耐药性。因此，建议对学生进行关于尿路感染传播和病因的健康教育。
