Huff W E, Kubena L F, Harvey R B, Doerr J A
Vet. Toxicol. and Entomol. Res. Lab., U.S. Department of Agriculture College Station, TX 77841.
J Anim Sci. 1988 Sep;66(9):2351-5. doi: 10.2527/jas1988.6692351x.
Mycotoxins are toxic compounds produced by fungi. When one mycotoxin is detected, one should suspect that others also are present in a contaminated feed ingredient or finished feeds. The toxicity and clinical signs of observed in animals when more than one mycotoxin is present in feed are complex and diverse. Some mycotoxins, such as the combination of aflatoxin with either ochratoxin A or T-2 toxin, interact to produce synergistic toxicity in broiler chicks. The effects observed during multiple mycotoxin exposure can differ greatly from the effects observed in animals exposed to a single mycotoxin. For example, fatty livers in poultry are used for presumptive diagnostic identification of aflatoxicosis. However, simultaneous presence of ochratoxin A prevents fatty livers. Of the mycotoxin combinations that have been investigated in poultry and swine, the aflatoxin + ochratoxin A and aflatoxin + T-2 toxin interactions appear to be the most toxic.
霉菌毒素是由真菌产生的有毒化合物。当检测到一种霉菌毒素时，就应该怀疑在受污染的饲料原料或成品饲料中还存在其他霉菌毒素。当饲料中存在多种霉菌毒素时，在动物身上观察到的毒性和临床症状复杂多样。一些霉菌毒素，如黄曲霉毒素与赭曲霉毒素A或T-2毒素的组合，会相互作用，在肉鸡雏鸡中产生协同毒性。在多种霉菌毒素暴露期间观察到的影响可能与在单一霉菌毒素暴露的动物中观察到的影响有很大不同。例如，家禽的脂肪肝用于黄曲霉毒素中毒的推定诊断识别。然而，赭曲霉毒素A的同时存在可防止脂肪肝的出现。在家禽和猪中研究过的霉菌毒素组合中，黄曲霉毒素+赭曲霉毒素A和黄曲霉毒素+T-2毒素的相互作用似乎毒性最强。
