Rheumatology Unit, Department of Internal Medicine, Neurology and Dermatology, University Hospital Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany.
Rheumatology Unit, Department of Internal Medicine, Neurology and Dermatology, University Hospital Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany.
Best Pract Res Clin Rheumatol. 2019 Jun;33(3):101435. doi: 10.1016/j.berh.2019.101435. Epub 2019 Sep 13.
Fatigue is a common, disabling, and difficult-to-manage problem in rheumatic diseases. The concept of fatigue is difficult to define. No clear and widely accepted definition of fatigue is available. The symptoms of fatigue are defined as an overwhelming, debilitating, and sustained sense of exhaustion that decreases the ability to function and carry out daily activities. Prevalence estimates of fatigue within musculoskeletal diseases vary considerably (35%-82%). In this review, we present data about the role of fatigue for the patients' quality of life, tools for diagnosing fatigue, factors contributing to fatigue like disease activity and psychological factors, and some experimental studies to verify the biological background of fatigue. Management of fatigue including pharmacological and non-pharmacological treatment is also part of this publication. Overall data are scarce for fatigue in rheumatic diseases, and further studies are warranted to identify the role of biological mechanism such as inflammation, hormonal changes, and autonomic nervous system in the pathogenesis of fatigue.
疲劳是风湿性疾病中常见的、使人丧失能力且难以治疗的问题。疲劳的概念很难定义。目前尚无明确且被广泛接受的疲劳定义。疲劳的症状被定义为压倒性的、使人虚弱的、持续的疲惫感，降低了功能和进行日常活动的能力。肌肉骨骼疾病中疲劳的患病率差异很大（35%-82%）。在这篇综述中，我们介绍了疲劳对患者生活质量的作用、诊断疲劳的工具、导致疲劳的因素，如疾病活动和心理因素，以及一些验证疲劳生物学背景的实验研究。疲劳的管理包括药物和非药物治疗，也是本出版物的一部分。风湿性疾病中疲劳的整体数据仍然有限，需要进一步研究以确定炎症、激素变化和自主神经系统等生物学机制在疲劳发病机制中的作用。
