Department of Rheumatology, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-900 Olsztyn, Poland.
Department of Pharmacology and Toxicology, Faculty of Medicine, University of Warmia and Mazury in Olsztyn, 10-082 Olsztyn, Poland.
Int J Mol Sci. 2023 Jul 27;24(15):12040. doi: 10.3390/ijms241512040.
Fatigue is a prevalent symptom in various rheumatic diseases, such as rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. It is characterised as a subjective, enduring feeling of generalised tiredness or exhaustion, impacting the patient's life quality and exacerbating disability. The fatigue nature is multifaceted, encompassing physiological, psychological, and social factors, and although the exact cause of inflammatory joint diseases is not fully understood, several factors are believed to contribute to its development. Despite high prevalence and importance, the symptom is often underestimated in clinical practice. Chronic inflammation, commonly associated with rheumatic diseases, has been proposed as a potential contributor to fatigue development. While current treatments effectively target inflammation and reduce disease activity, fatigue remains a persistent problem. Clinical evaluation of rheumatic diseases primarily relies on objective criteria, whereas fatigue, being a subjective symptom, is solely experienced and reported by the patient. Managing fatigue in inflammatory joint diseases involves a multifaceted approach. Identifying and comprehensively assessing the subjective components of fatigue in individual patients is crucial for effectively managing this symptom in everyday clinical practice.
疲劳是各种风湿性疾病的常见症状，如类风湿关节炎、银屑病关节炎和强直性脊柱炎。它的特点是一种主观的、持久的全身疲劳或疲惫感，影响患者的生活质量并加重残疾。疲劳的性质是多方面的，包括生理、心理和社会因素，尽管炎症性关节疾病的确切原因尚不完全清楚，但有几个因素被认为与其发展有关。尽管发病率高且重要，但该症状在临床实践中经常被低估。慢性炎症，通常与风湿性疾病相关，被认为是疲劳发展的一个潜在因素。虽然目前的治疗方法能有效靶向炎症并降低疾病活动度，但疲劳仍然是一个持续存在的问题。风湿性疾病的临床评估主要依赖于客观标准，而疲劳作为一种主观症状，仅由患者体验和报告。在炎症性关节疾病中管理疲劳需要采取多方面的方法。在日常临床实践中，识别和全面评估个体患者的疲劳的主观成分对于有效管理这种症状至关重要。
