Fan S T, Lau W Y, Teoh-Chan C H, Lau K F, Mauracher E H
Government Surgical Unit, Queen Mary Hospital, Hong Kong.
J Antimicrob Chemother. 1988 Jul;22(1):69-74. doi: 10.1093/jac/22.1.69.
The safety and efficacy of a single daily dose of netilmicin plus metronidazole after appendicectomy for gangrenous and perforated appendicitis was compared with the traditional thrice daily dosage. Twenty patients were enrolled in each group. The antibiotics were given intramuscularly for seven days after operation. Eradication of infection was observed in all patients and the postoperative wound sepsis was the same for each group. A significantly higher peak serum netilmicin level was achieved in the group receiving a single daily dose but nephrotoxicity was not observed. We concluded that the single daily dose of netilmicin was well tolerated and was as efficacious in this small series as the thrice daily regimen. The single-dose regimen has the advantage of simplicity and potentially increased bactericidal activity.
将坏疽性和穿孔性阑尾炎阑尾切除术后每日单次剂量的奈替米星加甲硝唑与传统的每日三次剂量进行安全性和有效性比较。每组纳入20例患者。术后抗生素肌肉注射7天。所有患者感染均得到根除，且每组术后伤口脓毒症情况相同。接受每日单次剂量的组血清奈替米星峰值水平显著更高，但未观察到肾毒性。我们得出结论，每日单次剂量的奈替米星耐受性良好，在这个小系列研究中与每日三次给药方案同样有效。单剂量方案具有简单的优点，且可能增强杀菌活性。
