Galløe A M, Graudal N, Christensen H R, Kampmann J P
Department of Medicine F, Herlev Hospital, Denmark.
Eur J Clin Pharmacol. 1995;48(1):39-43. doi: 10.1007/BF00202170.
A number of randomised studies indicate that a single high dose of aminoglycoside every 24 h may be more efficient and less toxic than the same dose divided into multiple daily doses. In the meta-analysis of 16 studies described here, which included more than 1200 patients, the relative chance (i.e. the relative risk, RR) of cure of the single-dose regime compared with the multiple-dose regime was 1.027, indicating that the single daily dose regime had a 2.7% higher cure rate (NS). The RR of avoiding nephrotoxicity was 1.001 (NS) and the RR of avoiding ototoxicity was 1.001 (NS). It is concluded that there is no difference concerning efficacy and safety between single-dose and multiple-dose regimes for administration of aminoglycosides.
多项随机研究表明，每24小时给予一次高剂量氨基糖苷类药物可能比将相同剂量分成多次每日剂量更有效且毒性更小。在本文所述的对16项研究的荟萃分析中，纳入了1200多名患者，单剂量方案与多剂量方案相比的治愈相对机会（即相对风险，RR）为1.027，表明每日单剂量方案的治愈率高2.7%（无统计学意义）。避免肾毒性的RR为1.001（无统计学意义），避免耳毒性的RR为1.001（无统计学意义）。得出的结论是，氨基糖苷类药物单剂量和多剂量给药方案在疗效和安全性方面没有差异。
