研究硫辛酸-4-甲氧基苄醇的反应及评价其分析用途。
Investigation of lipoic acid - 4-methoxybenzyl alcohol reaction and evaluation of its analytical usefulness.
机构信息
Institute of Chemistry, University of Białystok, ul. Ciołkowskiego 1K, 15-245 Białystok, Poland.
Institute of Chemistry, University of Białystok, ul. Ciołkowskiego 1K, 15-245 Białystok, Poland.
出版信息
Food Chem. 2020 Mar 30;309:125750. doi: 10.1016/j.foodchem.2019.125750. Epub 2019 Oct 23.
The presented work is aimed to synthesize a new UV active derivative of α-lipoic acid (ALA) by its esterification with 4-methoxybenzyl alcohol (4-MBA, anise alcohol). The formation of ester was confirmed by HNMR, FTIR and UV spectroscopy. The analytical usefulness of the obtained compound for quantification of ALA in food items was examined using HPLC-UV and GC-MS systems. It was found that it is possible to assay ALA in the ester form in the concentration ranges: 5·10-1·10 mol L by HPLC-UV and 1∙10-5∙10 mol L by GC-MS techniques. The GC-MS procedure was applied for the determination of ALA in the food samples.
本工作旨在通过α-硫辛酸（ALA）与 4-甲氧基苄醇（4-MBA，大茴香醇）酯化来合成其新型紫外活性衍生物。通过 HNMR、FTIR 和 UV 光谱证实了酯的形成。使用 HPLC-UV 和 GC-MS 系统检查了所得化合物在食品中定量测定 ALA 的分析用途。结果发现，通过 HPLC-UV 可以在 5·10-1·10 mol L 的浓度范围内测定酯形式的 ALA，通过 GC-MS 技术可以在 1∙10-5∙10 mol L 的浓度范围内测定。GC-MS 程序用于测定食品样品中的 ALA。
Zotero 插件