用人白血病T细胞系移植的仓鼠的眼部受累情况。
Ocular involvement in hamsters transplanted with a human leukemic T-cell line.
作者信息
Miyoshi I, Hiraki S, Nakamura K, Tanaka T, Kimura I
出版信息
Experientia. 1978 Aug 15;34(8):1089-90. doi: 10.1007/BF01915366.
PMID:700038
Abstract
A leukemic T-cell line (TALL-1) was serially transplanted for 5 passages into newborn hamsters treated with antilymphocyte serum. This cell line was derived from a leukemic patient with clinical evidence of ocular involvement. I.p. implantation of 1--3 X 10(7) cells resulted in disseminated growth of tumors in all 15 recipients after 23--41 days and 8 of them showed leukemic infiltration of the uveal tract of one or both eyes.
摘要
将一种白血病T细胞系（TALL-1）连续5代移植到用抗淋巴细胞血清处理过的新生仓鼠体内。该细胞系源自一名有眼部受累临床证据的白血病患者。腹腔注射1 - 3×10⁷个细胞，23 - 41天后，所有15只受体动物均出现肿瘤播散性生长，其中8只出现一只或双眼葡萄膜的白血病浸润。
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