Department of Colloid and Lipid Science, Faculty of Chemistry, Gdańsk University of Technology, Narutowicza Street 11/12, 80-233 Gdańsk, Poland.
Department of Colloid and Lipid Science, Faculty of Chemistry, Gdańsk University of Technology, Narutowicza Street 11/12, 80-233 Gdańsk, Poland.
Int J Pharm. 2019 Dec 15;572:118738. doi: 10.1016/j.ijpharm.2019.118738. Epub 2019 Nov 6.
Collagen and hyaluronic acid (HA) are biopolymers that affect the appearance and condition of the skin. Delivery of these compounds into the skin is highly challenging since have a number of disadvantageous properties, such as high molecular weight and hydrophilicity. Here, we evaluated the transdermal penetration of low and high molecular weight collagen and HA from microemulsions. A number of microemulsion formulations, differing in the content of polymers and surfactants (i.e. penetration promoters), were used for the permeation study. In addition, a correlation was made between the composition of these microemulsions and the polymers transport efficiency. The results indicate that, microemulsions enable transdermal permeation of collagen and HA. The concentration of polymers and the solubilization capacity of microemulsions had the greatest influence on the permeation. Surprisingly, the molecular weight of polymers and the content of other components affected the size of microemulsion particles, and thus these parameters had an indirect influence on the permeation process. This study demonstrated therefore the potential therapeutic use of microemulsion with collagen and HA in improving and regenerating the barrier of aged or diseased skin.
胶原蛋白和透明质酸（HA）是影响皮肤外观和状况的生物聚合物。由于具有分子量高和亲水性等多种不利特性，将这些化合物递送到皮肤中极具挑战性。在这里，我们评估了低分子量和高分子量胶原蛋白和 HA 从微乳液中的经皮渗透。使用了许多微乳液配方，这些配方在聚合物和表面活性剂（即渗透促进剂）的含量上有所不同，用于渗透研究。此外，还对这些微乳液的组成与聚合物传输效率之间的相关性进行了研究。结果表明，微乳液能够促进胶原蛋白和 HA 的经皮渗透。聚合物的浓度和微乳液的增溶能力对渗透有最大的影响。令人惊讶的是，聚合物的分子量和其他成分的含量影响了微乳液颗粒的大小，因此这些参数对渗透过程有间接影响。因此，这项研究表明，微乳液与胶原蛋白和 HA 的联合应用具有治疗潜力，可改善和再生老化或患病皮肤的屏障功能。
