Department of Colloid and Lipid Science, Faculty of Chemistry, Gdańsk University of Technology, Narutowicza 11/12, 80-233 Gdańsk, Poland.
Department of Colloid and Lipid Science, Faculty of Chemistry, Gdańsk University of Technology, Narutowicza 11/12, 80-233 Gdańsk, Poland.
Carbohydr Polym. 2017 Nov 1;175:347-354. doi: 10.1016/j.carbpol.2017.08.010. Epub 2017 Aug 5.
The increase in skin related health issues has promoted interest in research on the efficacy of microemulsion in dermal and transdermal delivery of active ingredients. Here, we assessed the water-in-oil microemulsion capacity to incorporate two natural polymers, i.e. collagen and hyaluronic acid with low and high molecular weight. Systems were extensively characterized in terms of conductivity, phase inversion studies, droplet diameter, polydispersity index and rheological properties. The results of this research indicate that the structure and extent of water phase in microemulsions is governed by ratio and amount of surfactant mixture (sorbitan ester derivatives). However, results have also shown that collagen, depending upon the weight of the molecule and its surface activity, influence the droplet size of the microemulsions. While the hyaluronic acid, especially with high molecular weight, due to the water-binding ability and hydrogel formation alters the rheological properties of the microemulsion, thus providing viscous consistency of the formulation.
皮肤相关健康问题的增加，推动了人们对微乳液在皮肤和透皮输送活性成分的功效的研究兴趣。在这里，我们评估了油包水型微乳液的能力，以纳入两种天然聚合物，即胶原和低分子和高分子量的透明质酸。从电导率、相转变研究、液滴直径、多分散指数和流变性能等方面对体系进行了广泛的表征。这项研究的结果表明，微乳液的水相结构和程度由表面活性剂混合物（山梨醇酯衍生物）的比例和数量决定。然而，结果还表明，胶原，取决于其分子量和表面活性，影响微乳液的液滴大小。而透明质酸，尤其是高分子量的透明质酸，由于其结合水的能力和水凝胶的形成，改变了微乳液的流变性能，从而提供了制剂的粘性稠度。
