Department of Plastic and Reconstructive Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China; Department of Plastic and Reconstructive Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
Department of Plastic and Reconstructive Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China; Department of Plastic and Reconstructive Surgery, Anqing municipal hospital, Anqing, Anhui Province, China.
J Surg Res. 2020 Mar;247:271-279. doi: 10.1016/j.jss.2019.09.069. Epub 2019 Nov 6.
The aim of this study was to evaluate the efficacy of autologous platelet-rich gel (APG) in the treatment of deep sinus tract wounds from diabetic ulcers.
Forty-eight patients with diabetic ulcers were randomly classified into two groups: an APG treatment group (25 patients) and a conventional wound dressing control group (23 patients). The sinus tract closure times, ulcer healing rates, hospitalization times, and hospitalization expenses of the two groups were compared.
There were no significant differences in the basic data and wound conditions between the two groups. The cure (healed wound) rates were 96% and 87% for the APG group and control group, respectively. During the first 4 wk, the sinus tract closure rate for the APG group was significantly higher than that for the control group. However, there was no significant difference in the sinus tract healing between the two groups at the end of the 8th wk. For the APG group and the control group, the average hospital stays were 19.36 ± 7.239 d and 48.13 ± 11.721 d, respectively, and the total hospitalization expenses were 2.48 ± 0.45 ten thousand yuan and 5.63 ± 1.35 ten thousand yuan (P < 0.05), respectively. These differences were statistically significant.
When compared with conventional wound dressings, APG can accelerate the healing of deep sinus tract wounds associated with diabetic ulcers.
本研究旨在评估自体富血小板凝胶（APG）治疗糖尿病溃疡深部窦道创面的疗效。
将 48 例糖尿病溃疡患者随机分为 APG 治疗组（25 例）和常规创面敷料对照组（23 例）。比较两组窦道闭合时间、溃疡愈合率、住院时间和住院费用。
两组患者的基本资料和创面情况比较差异无统计学意义。APG 组和对照组的治愈率（愈合创面）分别为 96%和 87%。在第 4 周内，APG 组窦道闭合率明显高于对照组。然而，在第 8 周结束时，两组窦道愈合情况无显著差异。APG 组和对照组的平均住院时间分别为 19.36±7.239 d 和 48.13±11.721 d，总住院费用分别为 2.48±0.45 万元和 5.63±1.35 万元（P<0.05），差异有统计学意义。
与常规创面敷料相比，APG 可加速糖尿病溃疡深部窦道创面的愈合。
