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一项前瞻性、干预性、对比研究，旨在评估在慢性伤口治疗中，使用富血小板血浆和富血小板纤维蛋白联合治疗相较于标准清洁和换药的疗效。

A Prospective, Interventional, Comparative Study to Evaluate the Efficacy of Using Combined Platelet-Rich Plasma and Platelet-Rich Fibrin Over Standard Cleaning and Dressing in Chronic Wounds.

作者信息

Gupta Sparsh, Zingade Anand, Baviskar Mayur, Pingale Shrikant V

机构信息

General Surgery, Yashwantrao Chavan Memorial Hospital, Pune, IND.

General Surgery, Pimpri Chinchwad Municipal Corporation's Postgraduate Institute, Yashwantrao Chavan Memorial Hospital, Pune, IND.

出版信息

Cureus. 2024 Sep 24;16(9):e70092. doi: 10.7759/cureus.70092. eCollection 2024 Sep.

DOI:10.7759/cureus.70092
PMID:39449930
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11500489/
Abstract

INTRODUCTION

Chronic wounds are defined as wounds that have failed to proceed through the orderly process that produces satisfactory anatomic and functional integrity or that have proceeded through the repair process without producing an adequate anatomic and functional result. The majority of wounds that have not healed in three months are considered chronic, although a duration as low as four weeks has been used to indicate chronicity. Our study aimed to compare the efficacy of autologous platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) versus standard cleaning and dressing as a regenerative medicine strategy to promote healing in chronic wounds.

METHODS

A prospective randomized controlled trial was undertaken to test the efficacy of autologous PRP and PRF in the healing of chronic wounds. A series of 60 cases was compiled from patients attending the outpatient department regularly for the management of chronic wounds. A total of 30 cases were randomly chosen for study with autologous PRP and PRF and 30 cases received conventional dressing.

RESULTS

The average healing duration in the study was significantly shorter for the PRP & PRF group. The mean healing time for this group was 4.45 weeks (31.2 ± 3.07 days) compared to 9.61 weeks (67.27 ± 9.19 days) for the conventional dressing group.

CONCLUSION

PRP and PRF belong to a new generation of platelet concentrates that help efficaciously for enhanced healing and functional recovery, safely and cost-effectively. They help by shortening the recovery period overall, improving the quality of life of patients, and altogether eliminating the additional morbidity of operative procedures.

摘要

引言

慢性伤口被定义为未能通过产生令人满意的解剖和功能完整性的有序过程，或者虽已通过修复过程但未产生足够的解剖和功能结果的伤口。大多数三个月未愈合的伤口被视为慢性伤口，尽管也有使用低至四周的持续时间来表明慢性。我们的研究旨在比较自体富血小板血浆（PRP）和富血小板纤维蛋白（PRF）与标准清洁和敷料作为促进慢性伤口愈合的再生医学策略的疗效。

方法

进行了一项前瞻性随机对照试验，以测试自体PRP和PRF在慢性伤口愈合中的疗效。从定期到门诊治疗慢性伤口的患者中收集了一系列60例病例。随机选择30例患者接受自体PRP和PRF治疗，30例患者接受传统敷料治疗。

结果

PRP和PRF组的平均愈合时间明显更短。该组的平均愈合时间为4.45周（31.2±3.07天），而传统敷料组为9.61周（67.27±9.19天）。

结论

PRP和PRF属于新一代血小板浓缩物，有助于有效促进愈合和功能恢复，安全且具有成本效益。它们通过总体上缩短恢复期、改善患者生活质量并完全消除手术额外的发病率来发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f23/11500489/21c3daff1c6b/cureus-0016-00000070092-i12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f23/11500489/9b321ddb1eb5/cureus-0016-00000070092-i01.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f23/11500489/e0ddef22e804/cureus-0016-00000070092-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f23/11500489/2e513272d2e8/cureus-0016-00000070092-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f23/11500489/177d8f2e9aef/cureus-0016-00000070092-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f23/11500489/0157bf1b3941/cureus-0016-00000070092-i09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f23/11500489/a538a25f4427/cureus-0016-00000070092-i10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f23/11500489/6b4e18a22de4/cureus-0016-00000070092-i11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f23/11500489/21c3daff1c6b/cureus-0016-00000070092-i12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f23/11500489/9b321ddb1eb5/cureus-0016-00000070092-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f23/11500489/04ef4756113f/cureus-0016-00000070092-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f23/11500489/d0c3f5590cd2/cureus-0016-00000070092-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f23/11500489/e238da2c7006/cureus-0016-00000070092-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f23/11500489/7036f108d369/cureus-0016-00000070092-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f23/11500489/e0ddef22e804/cureus-0016-00000070092-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f23/11500489/2e513272d2e8/cureus-0016-00000070092-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f23/11500489/177d8f2e9aef/cureus-0016-00000070092-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f23/11500489/0157bf1b3941/cureus-0016-00000070092-i09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f23/11500489/a538a25f4427/cureus-0016-00000070092-i10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f23/11500489/6b4e18a22de4/cureus-0016-00000070092-i11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f23/11500489/21c3daff1c6b/cureus-0016-00000070092-i12.jpg

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