遗传相互作用网络的进化与先天行为的遗传基础。
Evolution of Epistatic Networks and the Genetic Basis of Innate Behaviors.
机构信息
Department of Genetics and Biochemistry and Center for Human Genetics, Clemson University, Greenwood, SC, 29646, USA.
出版信息
Trends Genet. 2020 Jan;36(1):24-29. doi: 10.1016/j.tig.2019.10.005. Epub 2019 Nov 7.
Abstract
Instinctive behaviors are genetically programmed behaviors that occur independent of experience. How genetic programs that give rise to the manifestation of such behaviors evolve remains an unresolved question. I propose that evolution of species-specific innate behaviors is accomplished through progressive modifications of pre-existing genetic networks composed of allelic variants. I hypothesize that changes in frequencies of one or more constituent allelic variants within the network leads to changes in gene network connectivity and the emergence of a reorganized network that can support the emergence of a novel behavioral phenotype and becomes stabilized when key allelic variants are driven to fixation.
摘要
本能行为是独立于经验而发生的遗传编程行为。导致这些行为表现的遗传程序如何进化仍然是一个未解决的问题。我提出，物种特异性先天行为的进化是通过对由等位变体组成的预先存在的遗传网络进行渐进式修改来实现的。我假设网络中一个或多个组成等位变体的频率变化导致基因网络连接性的变化，并出现一个重新组织的网络，该网络可以支持新的行为表型的出现，并且当关键等位变体被驱动到固定状态时，网络会变得稳定。
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