Servicio de Endocrinología y Nutrición, Hospital de la Santa Creu i Sant Pau, Barcelona, España.
Servicio de Endocrinología y Nutrición, Hospital de la Santa Creu i Sant Pau, Barcelona, España; Departamento de Medicina, Universitat Autònoma de Barcelona, Bellaterra, España; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), España.
Endocrinol Diabetes Nutr (Engl Ed). 2020 Aug-Sep;67(7):461-468. doi: 10.1016/j.endinu.2019.07.010. Epub 2019 Nov 7.
The efficacy and safety of inpatient hyperglycemia management protocols using basal-bolus regimens have been widely demonstrated, but their implementation is insufficient. The aim of the study was to assess implementation and to establish the efficacy and safety of inpatient hyperglycemia management protocol based on a basal-bolus regimen and the incorporation of a nurse consultant.
Evaluation was performed at 10 hospital units. Data were retrospectively reviewed during hospital stay and 90 days after discharge in 400 patients after protocol implementation and 200 patients before implementation. The degree of satisfaction of professionals was assessed using a questionnaire 12 months after implementation.
The proportion of patients with basal-bolus regimens upon admission was higher in the postimplementation group (58% vs. 9%, P<0.001). Mean pre-prandial and bedtime blood glucose levels during admission were lower in the postimplementation group (164±41mg/L vs. 196±50mg/dL, P<0.001). After implementation, there were less patients with blood glucose levels >300mg/dL (36.3% vs. 50.5%, P<0.001) and more patients with values <70mg/dL (15% vs. 9%, P=0.040). Insulin addition and intensification was the main change in treatment at discharge, and a significant HbA1c reduction was seen three months after discharge in the postimplementation phase (P=0.04). The professionals assigned the protocol a score of 4.5 on a 1 to 5 scale.
Incorporation of a nurse consultant expert in diabetes as key component of a hyperglycemia management program ensures that a majority of patients admitted to hospital for hyperglycemia receive treatment with a basal-bolus regimen and improves blood glucose control during hospital stay and after discharge.
采用基础-餐时胰岛素方案的住院高血糖管理方案的疗效和安全性已得到广泛证实,但该方案的实施情况仍不理想。本研究旨在评估方案的实施情况,并评估基于基础-餐时胰岛素方案并纳入护士顾问的住院高血糖管理方案的疗效和安全性。
在 10 个医院科室进行评估。在方案实施后,对 400 例住院患者和实施前 200 例住院患者的住院期间和出院后 90 天的数据进行回顾性分析。实施 12 个月后,采用问卷评估专业人员的满意度。
实施后组入院时采用基础-餐时胰岛素方案的患者比例更高(58% vs. 9%,P<0.001)。实施后组患者入院时餐前和睡前的平均血糖水平更低(164±41mg/L vs. 196±50mg/dL,P<0.001)。实施后,血糖水平>300mg/dL 的患者更少(36.3% vs. 50.5%,P<0.001),血糖水平<70mg/dL 的患者更多(15% vs. 9%,P=0.040)。出院时胰岛素的添加和强化是治疗的主要变化,实施后组患者出院后 3 个月 HbA1c 显著降低(P=0.04)。专业人员给方案打了 4.5 分(满分 5 分)。
将糖尿病专科护士顾问作为高血糖管理方案的关键组成部分,可确保大多数因高血糖住院的患者接受基础-餐时胰岛素方案治疗,并改善住院期间和出院后的血糖控制。