Saha Cardiovascular Research Center and Department of Physiology, University of Kentucky, Lexington, KY, USA.
Saha Cardiovascular Research Center and Department of Physiology, University of Kentucky, Lexington, KY, USA.
Pharmacol Res. 2020 Jan;151:104537. doi: 10.1016/j.phrs.2019.104537. Epub 2019 Nov 7.
Megalin is a member of the low-density lipoprotein receptor superfamily. It has been recognized as an endocytic receptor for a large spectrum of ligands. As a consequence, megalin regulates homeostasis of many molecules and affects multiple physiological and pathophysiological functions. The renin-angiotensin system is a hormonal system. A number of studies have reported contributions of the renin-angiotensin system to atherosclerosis. There is evolving evidence that megalin is a regulator of the renin-angiotensin system, and contributes to atherosclerosis. This brief review provides contemporary insights into effects of megalin on renal functions, the renin-angiotensin system, and atherosclerosis.
巨球蛋白是 LDL 受体超家族的一员。它已被确认为多种配体的内吞受体。因此,巨球蛋白调节许多分子的动态平衡,并影响多种生理和病理生理功能。肾素-血管紧张素系统是一个激素系统。许多研究报告称肾素-血管紧张素系统参与动脉粥样硬化的形成。越来越多的证据表明巨球蛋白是肾素-血管紧张素系统的调节剂,并有助于动脉粥样硬化的形成。这篇简要综述提供了关于巨球蛋白对肾功能、肾素-血管紧张素系统和动脉粥样硬化影响的最新见解。