Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
SectionⅡ of Endocrinology & Nephropathy Department, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
Biomed Pharmacother. 2020 Jan;121:109599. doi: 10.1016/j.biopha.2019.109599. Epub 2019 Nov 7.
Diabetic nephropathy (DN) is a common but intractable diabetic microvascular complication. Tripterygium, a Chinses herb, has been proven to be effective for DN treatment. In this review, the efficacy and pharmacological mechanism of tripterygium and its extracts on DN is elucidated. Tripterygium and its extracts could effectively reduce urine protein and protect renal function. Its pharmacological mechanism involves anti-inflammation, anti-oxidation, anti-glomerulosclerosis and anti-fibrosis, which is achieved by balancing the Th1/Th2 cells, regulating macrophage infiltration, and regulating the following pathways: p38 MAPK, NF-κB, TGF-β, Wnt/β-catenin, Akt and Notch1. Although tripterygium and its extracts may result in some adverse effects, including liver-function damage, gastrointestinal reaction, menstrual disorders, and reproductive problems, they are considered good alternative medicines for DN if used with caution and in the proper manner.
糖尿病肾病（DN）是一种常见但棘手的糖尿病微血管并发症。雷公藤，一种中国草药，已被证明对 DN 的治疗有效。在这篇综述中，阐述了雷公藤及其提取物对 DN 的疗效和药理机制。雷公藤及其提取物能有效减少尿蛋白，保护肾功能。其药理机制涉及抗炎、抗氧化、抗肾小球硬化和抗纤维化，这是通过平衡 Th1/Th2 细胞、调节巨噬细胞浸润以及调节以下途径来实现的：p38 MAPK、NF-κB、TGF-β、Wnt/β-catenin、Akt 和 Notch1。虽然雷公藤及其提取物可能会导致一些不良反应，包括肝功能损害、胃肠道反应、月经紊乱和生殖问题，但如果谨慎和正确使用，它们被认为是治疗 DN 的良好替代药物。
