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早期引入花生预防过敏发展的最新进展:实施面临的挑战。

Update on Early Introduction of Peanut to Prevent Allergy Development: Challenges with Implementation.

机构信息

Nationwide Children's Hospital, Division of Allergy and Immunology, The Ohio State University College of Medicine, 700 Children's Drive, ED - 6022, Columbus, OH, 43205, USA.

出版信息

Curr Allergy Asthma Rep. 2019 Nov 9;19(11):51. doi: 10.1007/s11882-019-0884-0.

DOI:10.1007/s11882-019-0884-0
PMID:31707607
Abstract

PURPOSE OF REVIEW

This review summarizes the evidence leading towards the development of new guidelines that recommend early introduction of peanut to prevent the development of peanut allergy. It also reviews the current understanding of challenges faced with implementation of these recommendations on a widespread basis.

RECENT FINDINGS

Prior recommendations to avoid feeding allergenic foods to infants have been updated and reversed. This paradigm shift in advice has created an opportunity on a population level to try and halt the recent increase in prevalence of peanut allergy. However, challenges with implementation of these new guidelines exist in many areas. While evidence supports the early introduction of peanut to prevent allergy development, the application and challenges faced with these recommendations are not fully understood. Persistent efforts from pediatricians and allergists, as well as acceptance from parents, will be necessary in order to make a significant impact on the prevalence of peanut allergy.

摘要

目的综述

本文总结了推荐早期引入花生以预防花生过敏新指南发展的证据。本文还综述了在广泛基础上实施这些建议所面临的挑战的现有理解。

最近的发现

避免给婴儿食用致敏食物的先前建议已经被更新和推翻。这种建议的转变为尝试阻止近期花生过敏流行率的上升提供了一个机会。然而,在许多领域实施这些新指南存在挑战。虽然有证据支持早期引入花生以预防过敏发展,但这些建议的应用和面临的挑战尚未完全理解。为了对花生过敏的流行率产生重大影响,儿科医生和过敏学家需要持续努力,同时也需要家长的认可。

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本文引用的文献

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Earlier ingestion of peanut after changes to infant feeding guidelines: The EarlyNuts study.改变婴幼儿喂养指南后更早摄入花生:EarlyNuts 研究。
J Allergy Clin Immunol. 2019 Nov;144(5):1327-1335.e5. doi: 10.1016/j.jaci.2019.07.032. Epub 2019 Aug 8.
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The Australasian Society of Clinical Immunology and Allergy infant feeding for allergy prevention guidelines.《澳大利亚临床免疫和过敏学会婴幼儿喂养预防过敏指南》。
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Knowledge gaps and barriers to early peanut introduction among allergists, pediatricians, and family physicians.
过敏症专科医生、儿科医生和家庭医生在早期引入花生方面的知识差距和障碍。
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"To screen or not to screen": Comparing the health and economic benefits of early peanut introduction strategies in five countries.“筛查还是不筛查”:比较五个国家早期引入花生策略的健康和经济效益。
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Caregiver and expecting caregiver support for early peanut introduction guidelines.照顾者和准照顾者对早期引入花生的指导方针的支持。
Ann Allergy Asthma Immunol. 2018 Jun;120(6):620-625. doi: 10.1016/j.anai.2018.03.001. Epub 2018 Mar 7.
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Implementation of guidelines for early peanut introduction at a pediatric academic center.在一家儿科学术中心实施早期引入花生的指南。
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Is Skin Testing or sIgE Testing Necessary Before Early Introduction of Peanut for Prevention of Peanut Allergy?在早期引入花生以预防花生过敏之前,是否需要进行皮肤试验或特异性IgE检测?
J Allergy Clin Immunol Pract. 2018 Mar-Apr;6(2):408-413. doi: 10.1016/j.jaip.2017.08.011. Epub 2017 Sep 28.
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Addendum guidelines for the prevention of peanut allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases-sponsored expert panel.美国预防花生过敏补充指南:美国国立过敏与传染病研究所资助的专家小组报告
J Allergy Clin Immunol. 2017 Jan;139(1):29-44. doi: 10.1016/j.jaci.2016.10.010.
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Understanding the feasibility and implications of implementing early peanut introduction for prevention of peanut allergy.了解实施早期花生引入预防花生过敏的可行性和影响。
J Allergy Clin Immunol. 2016 Oct;138(4):1131-1141.e2. doi: 10.1016/j.jaci.2016.04.011. Epub 2016 May 2.