Department of Microbiology, The Ohio State University, Mansfield, OH 44906.
Adv Drug Deliv Rev. 2019 May;145:18-39. doi: 10.1016/j.addr.2018.06.018. Epub 2018 Jul 3.
Viruses of bacteria - known as bacteriophages or phages - have been used clinically as antibacterial agents for nearly 100 years. Often this phage therapy is of long-standing, persistent, or chronic bacterial infections, and this can be particularly so given prior but insufficiently effective infection treatment using standard antibiotics. Such infections, in turn, often have a biofilm component. Phages in modern medicine thus are envisaged to serve especially as anti-biofilm/anti-persistent infection agents. Here I review the English-language literature concerning in vivo experimental and clinical phage treatment of longer-lived bacterial infections. Overall, published data appears to be supportive of a relatively high potential for phages to cure infections which are long standing and which otherwise have resisted treatment with antibieiotics.
细菌病毒——又称噬菌体或噬菌体能在临床上作为抗菌剂使用近 100 年。这种噬菌体疗法通常用于治疗长期、持续或慢性细菌感染，而且在使用标准抗生素进行先前但效果不足的感染治疗后，这种情况尤其如此。这种感染往往具有生物膜成分。因此，噬菌体在现代医学中被认为是专门用于抗生物膜/抗持续性感染的药物。在这里，我回顾了有关体内实验和临床噬菌体治疗持久性细菌感染的英文文献。总的来说，已发表的数据似乎支持噬菌体治愈长期存在且对抗生素治疗有抵抗力的感染的潜力相对较高。
