Division of Pediatric Dentistry, Faculdade São Leopoldo Mandic, Campinas, SP, Brazil.
Department of Dentistry, Federal University of Santa Catarina, Florianópolis, SC, Brazil.
Dentomaxillofac Radiol. 2020 Oct 1;49(7):20190347. doi: 10.1259/dmfr.20190347. Epub 2019 Nov 20.
To investigate the validity of micro-CT for caries detection in comparison with histology as the reference standard.
A systematic search was conducted in the databases Latin American and Caribbean Health Sciences (LILACS), LIVIVO, PubMed, Scopus and Web of Science from their inception to 16 January 2019. Grey literature was searched on Open Grey, ProQuest Dissertations and Theses Database and Google Scholar. studies assessing the validity of micro-CT for caries detection were included when compared with histology as the reference standard were included. Two authors independently collected the information and sensitivity, specificity, positive and negative likelihood ratios, as well as diagnostic odds ratios were calculated. The risk of bias of the included studies was assessed using the QUADAS-2 tool. Certainty of evidence was assessed with GRADE.
A total of 270 papers were identified, and after a 2-phase selection, 12 studies were included in qualitative and three in quantitative synthesis. For enamel caries diagnostic, sensitivity values ranged from 29.0 to 84.0% indicating high variability while specificity varied from 88.0 to 95.0% indicating good to excellent micro-CT capability do identify the true negative. For dentine caries diagnostic, sensitivity values ranged from 61.0 to 77.0% indicating fair-to-good probability of micro-CT to identify the true positives, while specificity varied from 88.0 to 94.0%. The majority of the included studies presented low risk of bias and moderate certainty of evidence.
This study demonstrated the validity of micro-CT for caries detection in comparison with histology.
与组织病理学作为参考标准相比，研究微计算机断层扫描（micro-CT）在龋齿检测中的有效性。
系统检索拉丁美洲和加勒比健康科学（LILACS）、LIVIVO、PubMed、Scopus 和 Web of Science 数据库，检索时间从建库至 2019 年 1 月 16 日。在 Open Grey、ProQuest Dissertations and Theses Database 和 Google Scholar 上搜索灰色文献。纳入与组织病理学作为参考标准比较评估 micro-CT 对龋齿检测的有效性的研究。两位作者独立收集信息，并计算了敏感性、特异性、阳性似然比、阴性似然比以及诊断比值比。使用 QUADAS-2 工具评估纳入研究的偏倚风险。使用 GRADE 评估证据的确定性。
共确定了 270 篇论文，经过 2 阶段筛选，12 项研究纳入定性分析，3 项研究纳入定量合成。对于牙釉质龋的诊断，敏感性值范围为 29.0%至 84.0%，表明存在高度变异性，而特异性值范围为 88.0%至 95.0%，表明 micro-CT 具有良好到极好的能力来识别真正的阴性。对于牙本质龋的诊断，敏感性值范围为 61.0%至 77.0%，表明 micro-CT 有一定的可能性识别真正的阳性，而特异性值范围为 88.0%至 94.0%。纳入的大多数研究存在低偏倚风险和中等确定性证据。
与组织病理学相比，本研究证明了 micro-CT 在龋齿检测中的有效性。
