Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Henan Key Laboratory of Laboratory Medicine, Zhengzhou 450052, Henan, China.
The 32144 troops of the Chinese People's Liberation Army, Weinan 714000, Shanxi, China.
Thromb Res. 2019 Dec;184:81-85. doi: 10.1016/j.thromres.2019.09.030. Epub 2019 Oct 30.
There has been little published work about the reference intervals of thromboelastography (TEG®) tests in pregnancy. Our aim was to establish the trimester-specific reference intervals of TEG tests for healthy pregnant women.
After excluding outliers, a total of 753 apparently healthy pregnant women aged from 19 to 44 years including 252 first trimester women, 340 second trimester women and 161 third trimester women were enrolled in our study. Non-fasting venous blood samples were collected. TEG tests were done on kaolin activated samples and processed on TEG 5000 Hemostasis Analyzer. Nonparametric 2.5th-97.5th percentile intervals were used to define the reference intervals.
There were significant differences for TEG tests in pregnant women compared with non-pregnant women. The reference intervals for R, K, Angle, MA, Ly30 and CI were 4.1-10.4 min, 0.9-3.1 min, 53.6-75.9°, 46.1-69.8 mm, 0-10.7% and -5.5-2.5 respectively at first trimester; 3.9-9.7 min, 0.8-2.4 min, 56.7-78.0°, 49.8-72.1 mm, 0-9.7% and -3.7-2.9 at second trimester; 3.8-9.0 min, 0.8-2.5 min, 57.6-79.3°, 49.4-75.9 mm, 0-8.8% and -3.0-2.6 at third trimester.
We established trimester-specific reference intervals of TEG® tests for healthy pregnant women. It's critical to accurate assessment of global haemostatic status during pregnancy and in pregnancy complications.
关于血栓弹力图（TEG®）检测在妊娠中的参考区间，相关文献报道较少。本研究旨在建立健康孕妇各孕期TEG 检测的特定孕期参考区间。
排除离群值后，共纳入年龄 19-44 岁的 753 例健康孕妇，其中 252 例处于孕早期，340 例处于孕中期，161 例处于孕晚期。采集非空腹静脉血样，在 TEG 5000 血栓弹力仪上对高岭土激活样本进行 TEG 检测。采用非参数 2.5 百分位-97.5 百分位区间定义参考区间。
与非妊娠女性相比，孕妇的 TEG 检测结果存在显著差异。孕早期 R、K、Angle、MA、Ly30 和 CI 的参考区间分别为 4.1-10.4min、0.9-3.1min、53.6-75.9°、46.1-69.8mm、0-10.7%和-5.5-2.5；孕中期 R、K、Angle、MA、Ly30 和 CI 的参考区间分别为 3.9-9.7min、0.8-2.4min、56.7-78.0°、49.8-72.1mm、0-9.7%和-3.7-2.9；孕晚期 R、K、Angle、MA、Ly30 和 CI 的参考区间分别为 3.8-9.0min、0.8-2.5min、57.6-79.3°、49.4-75.9mm、0-8.8%和-3.0-2.6。
本研究建立了健康孕妇 TEG®检测的特定孕期参考区间，对于准确评估孕期及妊娠并发症时的整体凝血状态具有重要意义。
