Sun Jun-Bo, Bian Mao-Hong, Zhong Tao, Lu Ying-Yu, Zhu Bang-Qiang, Wen Hui-Qin, Hu Hai-Liang
Department of Blood Transfusion, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Department of Blood Transfusion, The Second Hospital of Anhui Medical University, Hefei, Anhui, China.
J Clin Lab Anal. 2017 Nov;31(6). doi: 10.1002/jcla.22128. Epub 2017 Jan 30.
The assessment of the coagulation status using thromboelastography (TEG) in Chinese population has less been reported. This study aimed to establish reliable reference values for kaolin-activated TEG in Chinese volunteers.
A total of 1681 Chinese adult individuals were recruited for this study. The reference individuals were stratified by gender and age, and the TEG values were measured on the basis of strict quality control. The 95% reference values were determined using nonparametric statistical methods.
The sex-related 95% reference values were reaction time (R):4.2-8.7 minutes; clotting time (K): 1.2-3.2 minutes; alpha angle (α): 47.0-72.3 degree; maximum amplitude (MA): 49.1-70.5 mm for males, and R: 3.7-9.0 minutes; K: 1.0-3.2 minutes; α: 48.4-74.4 degree; MA: 46.8-72.4 mm for females. Also, the TEG parameters indicated a relatively more hypercoagulable profile in both female and elder groups.
This study established the reference values for kaolin-activated TEG in the target Chinese population, which might provide a reference for both clinical and laboratory studies.
在中国人群中，运用血栓弹力图（TEG）评估凝血状态的相关报道较少。本研究旨在为中国志愿者建立高岭土激活的TEG可靠参考值。
本研究共招募了1681名中国成年个体。参考个体按性别和年龄分层，并在严格的质量控制基础上测量TEG值。采用非参数统计方法确定95%参考值。
与性别相关的95%参考值为：男性反应时间（R）：4.2 - 8.7分钟；凝血时间（K）：1.2 - 3.2分钟；α角（α）：47.0 - 72.3度；最大振幅（MA）：49.1 - 70.5毫米；女性R：3.7 - 9.0分钟；K：1.0 - 3.2分钟；α：48.4 - 74.4度；MA：46.8 - 72.4毫米。此外，TEG参数表明女性和老年组的凝血状态相对更倾向于高凝。
本研究建立了目标中国人群中高岭土激活的TEG参考值，可为临床和实验室研究提供参考。
