Tamura N, Baverstock J, McLeod J G
Department of Medicine, University of Sydney, Australia.
J Auton Nerv Syst. 1988 Jun;23(1):9-15. doi: 10.1016/0165-1838(88)90161-0.
Morphometric studies were performed on the myelinated fibres of the carotid sinus nerve obtained at autopsy from 13 control subjects, 7 patients with diabetes mellitus and 11 with chronic alcoholism. The myelinated fibre-diameter distribution in control nerves was bimodal with peaks at 3-4 micron and at 8-10 micron. The mean myelinated fibre density was 14.8 X 10(3)/mm2 (SD 2.3 X 10(3)/mm2) in control nerves and was significantly reduced in the nerves of diabetics (mean, 11.7 X 10(3)/mm2; SD, 2.2 X 10(3)/mm2), and chronic alcoholics (mean, 12.7 X 10(3)/mm2; SD, 2.1 X 10(3)/mm2), although in 8 of 11 nerves from alcoholics, the density was within the control range. These findings demonstrate that autonomic afferent fibres are damaged in diabetes and chronic alcoholism, and provide a pathological basis for the disturbances of heart rate and blood pressure control in these conditions.
对13名对照受试者、7名糖尿病患者和11名慢性酒精中毒患者尸检时获取的颈动脉窦神经有髓纤维进行了形态测量研究。对照神经的有髓纤维直径分布呈双峰状，峰值分别在3 - 4微米和8 - 10微米处。对照神经中有髓纤维的平均密度为14.8×10³/mm²（标准差为2.3×10³/mm²），糖尿病患者神经中的有髓纤维平均密度显著降低（平均为11.7×10³/mm²；标准差为2.2×10³/mm²），慢性酒精中毒患者神经中的有髓纤维平均密度也显著降低（平均为12.7×10³/mm²；标准差为2.1×10³/mm²），不过在11名慢性酒精中毒患者的神经中，有8根神经的密度在对照范围内。这些发现表明自主神经传入纤维在糖尿病和慢性酒精中毒中受到损伤，并为这些情况下心率和血压控制紊乱提供了病理基础。
