Department of Oral and Maxillofacial Radiology, Academic Center for Dentistry Amsterdam ACTA, Amsterdam, The Netherlands.
Department of Oral and Maxillofacial Surgery, Amsterdam UMC University of Amsterdam, Amsterdam, The Netherlands.
Dentomaxillofac Radiol. 2020 Mar;49(3):20190275. doi: 10.1259/dmfr.20190275. Epub 2019 Nov 18.
In paediatric cancer survivors treated with chemotherapy and radiotherapy therapy, late effects on dental development are quite common. Oral radiologists are not familiar with the radiographic images of these specific dental consequences of chemotherapy and radiotherapy. With the goal of educating colleagues, to raise awareness of the needs of survivors, and to identify directions for future research, we present dental radiographs of survivors treated for head and neck rhabdomyosarcoma with chemotherapy and radiotherapy. Also, based on the survivors reviewed, a radiographic inventory of commonly found late dental developmental effects seen in conjunction with treatment is presented.
Panoramic radiographic findings of five illustrative cases are presented, from a group of 42 survivors of head and neck rhabdomyosarcoma treated at the Academic Medical Center Amsterdam, The Netherlands over the past 25 years.
Five cases showing dental developmental disorders are presented. These cases show an association of the location of the radiation field and the developmental stage of the teeth with the severity of the effect on dental development. We also report an inventory of severe and moderate effects of chemotherapy and radiotherapy on the development of molars and anterior teeth.
This paper presents five cases and a radiographic inventory to illustrate disturbances of dental development associated with chemotherapy and radiotherapy in children. Medical and dental professionals involved in the treatment of cancer survivors are relatively unaware of the dental consequences of radiation therapy and the age dependency of specific regional effects. These effects can be severe, with great impact on quality of life. Further research in this area could help improve planning of radiation therapy for children, potentially preventing or limiting dental or maxillofacial sequelae.
在接受化疗和放疗治疗的儿科癌症幸存者中，牙齿发育的晚期影响较为常见。口腔放射科医生并不熟悉这些化疗和放疗特定的牙齿后果的放射影像学表现。为了教育同行，提高对幸存者需求的认识，并确定未来研究的方向，我们展示了 5 例经化疗和放疗治疗头颈部横纹肌肉瘤的幸存者的口腔 X 光片。此外，根据对这些幸存者的回顾，我们提出了一种常见的与治疗相关的晚期牙齿发育不良的 X 光片表现的放射学清单。
我们展示了来自荷兰阿姆斯特丹学术医学中心的 42 例头颈部横纹肌肉瘤幸存者的 5 例典型病例的全景 X 光片。
我们展示了 5 例显示牙齿发育障碍的病例。这些病例显示出放射野的位置与牙齿的发育阶段与对牙齿发育影响的严重程度之间存在关联。我们还报告了化疗和放疗对磨牙和前牙发育的严重和中度影响的清单。
本文展示了 5 个病例和一个放射学清单，以说明与儿童化疗和放疗相关的牙齿发育紊乱。参与癌症幸存者治疗的医疗和牙科专业人员对放射治疗的牙齿后果以及特定区域影响的年龄依赖性相对缺乏了解。这些影响可能很严重，对生活质量有重大影响。在这一领域进一步研究可能有助于改善儿童放射治疗的规划，从而有可能预防或限制牙齿或颌面的后遗症。
