Department of Biomedical and NeuroMotor Sciences (DiBiNeM), Unit of Dental Care for Special Needs Patients and Paediatric Dentistry, University of Bologna, Bologna, Italy.
Unit of Paediatric Oncology, Sant'Orsola Hospital University of Bologna, Bologna, Italy.
Eur J Paediatr Dent. 2014 Mar;15(1):45-50.
To investigate with a reliable method the oral features in Italian patients in remission from cancer, highlighting the relationship with age at cancer therapy and to compare the data with healthy controls.
Twenty five childhood cancer survivors treated under the age of 10 years with chemotherapy w/wo Haemopoietic Stem Cell Transplantation and/or head-neck Radiotherapy, in remission from cancer for at least 3 years, were examined for dental caries and enamel defects. To assess dental age and dental abnormalities a panoramic radiograph was taken. Patients were grouped according to age at cancer therapy (<3 years: subgroup Y; 3.1-5 years: subgroup M; >5 years: subgroup O). A control group of 26 healthy children was included.
There was not a statistically significant difference in caries prevalence between the two groups. A statistically significant difference between the two groups was found for enamel defects, dental abnormalities and dental age. The chi-squared test revealed a relationship between age at therapy and specific dental abnormalities.
This study shows that cancer therapy may increase the risk of development of enamel defects and dental abnormalities, especially in children treated under the age of 3 years.
用可靠的方法研究意大利癌症缓解期患者的口腔特征，强调癌症治疗年龄与健康对照组数据的关系。
对 25 名接受过化疗、造血干细胞移植和/或头颈部放疗的儿童癌症幸存者进行检查，这些患者在癌症缓解期至少 3 年，年龄均在 10 岁以下，检查龋齿和牙釉质缺陷。为了评估牙龄和牙齿异常，拍摄了全景片。根据癌症治疗年龄将患者分为三组(<3 岁：Y 组；3.1-5 岁：M 组；>5 岁：O 组)。同时纳入 26 名健康儿童作为对照组。
两组间龋齿患病率无统计学差异。两组间牙釉质缺陷、牙齿异常和牙龄有统计学差异。卡方检验显示治疗年龄与特定牙齿异常之间存在关系。
本研究表明，癌症治疗可能会增加牙釉质缺陷和牙齿异常的风险，尤其是在 3 岁以下接受治疗的儿童。
