Key Laboratory of Environmental Medicine Engineering in Ministry of Education, Medical School, Southeast University, Nanjing 210009, China.
Key Laboratory of Environmental Medicine Engineering in Ministry of Education, Medical School, Southeast University, Nanjing 210009, China.
Sci Total Environ. 2020 Feb 10;703:134817. doi: 10.1016/j.scitotenv.2019.134817. Epub 2019 Oct 31.
Sulfonate modified polystyrene is potentially used in medical application; however, the effect of sulfonate modification on polystyrene toxicity is still largely unclear. We here compared the neurotoxicity between pristine and sulfonate modified nanopolystyrene particles in nematode Caenorhabditis elegans. Exposure to nanopolystyrene (35 nm) caused neurotoxicity on locomotion behaviors (head thrash, body bend, forward movement, and backward movement) and sensory perception behaviors (chemotaxis to NaCl or diacetyl). Exposure to nanopolystyrene also induced the damage on development of dopaminergic neurons as reflected by relative fluorescence intensity, number of discontinuous dendrite, and number of abnormal cell body. Moreover, we found that sulfonate modification effectively enhanced the neurontoxicity of nanopolystyrene on locomotion behaviors, sensory perception behaviors, and development of dopaminergic neurons. Our results highlight the possibility of sulfonate modification in increasing neurotoxicity of nanopolystyrene exposure on environmental organisms.
磺酸盐改性聚苯乙烯在医学应用中具有潜在用途；然而，磺酸盐改性对聚苯乙烯毒性的影响在很大程度上仍不清楚。我们在这里比较了原始和磺酸盐改性纳米聚苯乙烯颗粒在秀丽隐杆线虫中的神经毒性。暴露于纳米聚苯乙烯（35nm）会导致运动行为（头部抽搐、身体弯曲、向前运动和向后运动）和感觉感知行为（对 NaCl 或双乙酰的趋化性）的神经毒性。暴露于纳米聚苯乙烯还会导致多巴胺能神经元的发育损伤，表现为相对荧光强度、不连续树突的数量和异常细胞体的数量减少。此外，我们发现磺酸盐改性可有效增强纳米聚苯乙烯对运动行为、感觉感知行为和多巴胺能神经元发育的神经毒性。我们的结果强调了磺酸盐改性可能会增加环境生物暴露于纳米聚苯乙烯的神经毒性。
