邻里贫困对胚胎生长轨迹的影响：鹿特丹围孕期队列研究
The Impact of Neighbourhood Deprivation on Embryonic Growth Trajectories: Rotterdam Periconception Cohort.
作者信息
Gootjes Dionne V, Koster Maria P H, Willemsen Sten P, Koning Anton H J, Steegers Eric A P, Steegers-Theunissen Régine P M
机构信息
Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam 3015 GD, The Netherlands.
Department of Biostatistics, Erasmus MC, University Medical Centre Rotterdam, Rotterdam 3015 GD, The Netherlands.
出版信息
J Clin Med. 2019 Nov 8;8(11):1913. doi: 10.3390/jcm8111913.
BACKGROUND
Neighbourhood deprivation is a risk factor for impaired health and adverse pregnancy outcomes. We investigated whether living in a deprived neighbourhood is associated with embryonic growth.
METHODS
From the Predict cohort, we studied 566 women who underwent repeated first trimester ultrasound examinations. Crown rump length (CRL; = 1707) and embryonic volume (EV; = 1462) were measured using three-dimensional techniques. Neighbourhood deprivation was assessed using the neighbourhood status scores (NSS) of the Dutch Social Cultural Planning office. A high NSS represents a non-deprived neighbourhood. Associations between the NSS and embryonic growth were investigated using linear mixed models. Adjustment was performed for individual-level factors: maternal age, geographic origin, educational level, BMI, folic acid supplement use, fruit and vegetable intake, alcohol use and smoking habits.
RESULTS
The NSS was negatively associated with embryonic growth: a higher score (a less deprived neighbourhood) was associated with a smaller CRL and EV; adjusted β: -0.025 (95% CI -0.046, -0.003) and adjusted β: -0.015 (95% CI -0.026, -0.003). At 11 weeks of pregnancy, we observed a 0.55 cm smaller EV (7.65 cm vs. 7.10 cm) and 1.08 mm smaller CRL (43.14 mm vs. 42.06 mm) in the highest compared to the lowest category.
CONCLUSION
In deprived neighbourhoods, embryos are larger than in non-deprived neighbourhoods.
背景
社区贫困是健康受损和不良妊娠结局的一个风险因素。我们调查了生活在贫困社区是否与胚胎生长有关。
方法
从Predict队列中，我们研究了566名接受孕早期重复超声检查的女性。使用三维技术测量头臀长度（CRL；n = 1707）和胚胎体积（EV；n = 1462）。使用荷兰社会文化规划办公室的社区状况评分（NSS）评估社区贫困程度。高NSS代表非贫困社区。使用线性混合模型研究NSS与胚胎生长之间的关联。对个体水平因素进行了调整：产妇年龄、地理来源、教育水平、体重指数、叶酸补充剂使用情况、水果和蔬菜摄入量、饮酒情况和吸烟习惯。
结果
NSS与胚胎生长呈负相关：得分越高（社区贫困程度越低），CRL和EV越小；调整后的β值：-0.025（95%置信区间-0.046，-0.003）和调整后的β值：-0.015（95%置信区间-0.026，-0.003）。在怀孕11周时，我们观察到最高类别与最低类别相比，EV小0.55厘米（7.65厘米对7.10厘米），CRL小1.08毫米（43.14毫米对42.06毫米）。
结论
在贫困社区，胚胎比非贫困社区的胚胎更大。
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