Department of Obstetrics and Gynecology, Erasmus MC, University Medical Centre, PO Box 2040, 3000 CA, Rotterdam, Netherlands.
Department of Pediatrics, Division of Neonatology, Erasmus MC, University Medical Centre, 3015 GD, Rotterdam, Netherlands.
Eur J Clin Nutr. 2018 Dec;72(12):1655-1662. doi: 10.1038/s41430-018-0161-7. Epub 2018 Apr 20.
BACKGROUND/OBJECTIVES: Maternal dietary patterns were associated with embryonic growth and congenital anomalies. We aim to evaluate associations between early first trimester maternal dietary patterns and embryonic morphological development among pregnancies with non-malformed outcome.
SUBJECTS/METHODS: A total of 228 strictly dated, singleton pregnancies without congenital malformations were enrolled in a periconceptional hospital-based cohort. Principal component analysis was performed to extract early first trimester maternal dietary patterns from food frequency questionnaires. Serial transvaginal three-dimensional ultrasound (3D US) scans were performed between 6 and 10 gestational weeks and internal and external morphological criteria were used to define Carnegie stages in a virtual reality system. Associations between dietary patterns and Carnegie stages were investigated using linear mixed models.
A total of 726 3D US scans were included (median: three scans per pregnancy). The 'high fish and olive oil and low meat' dietary pattern was associated with accelerated embryonic development in the study population (β = 0.12 (95%CI: 0.00; 0.24), p < 0.05). Weak adherence to this dietary pattern delayed embryonic development by 2.1 days (95%CI: 1.6; 2.6) compared to strong adherence. The 'high vegetables, fruit and grain' dietary pattern accelerated embryonic development in the strictly dated spontaneous pregnancy subgroup without adjustment for energy intake.
Early first trimester maternal dietary patterns impacts human embryonic morphological development among pregnancies without congenital malformations. The clinical meaning of delayed embryonic development needs further investigation.
背景/目的：母体饮食模式与胚胎生长和先天畸形有关。我们旨在评估非畸形妊娠中早期妊娠早期母体饮食模式与胚胎形态发育之间的关系。
对象/方法：共纳入 228 例严格日期、无先天畸形的单胎妊娠，纳入一项基于医院的围孕期队列研究。采用主成分分析法从食物频率问卷中提取早期妊娠早期母体饮食模式。在 6 至 10 孕周之间进行经阴道三维超声（3D US）连续扫描，并在虚拟现实系统中使用内部和外部形态标准定义卡内基阶段。使用线性混合模型研究饮食模式与卡内基阶段之间的关系。
共纳入 726 例 3D US 扫描（中位数：每例妊娠三次扫描）。“高鱼和橄榄油、低肉”饮食模式与研究人群中胚胎发育加速有关（β=0.12（95%CI：0.00；0.24），p<0.05）。与强烈依从相比，这种饮食模式较弱的依从性使胚胎发育延迟 2.1 天（95%CI：1.6；2.6）。“高蔬菜、水果和谷物”饮食模式在未调整能量摄入的严格日期自发性妊娠亚组中加速了胚胎发育。
早期妊娠早期母体饮食模式影响无先天畸形妊娠的人类胚胎形态发育。胚胎发育延迟的临床意义需要进一步研究。
