Department of Obstetrics and Gynecology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands.
Department of Bioinformatics, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands.
Ultrasound Obstet Gynecol. 2017 Dec;50(6):709-716. doi: 10.1002/uog.17408. Epub 2017 Nov 2.
To investigate the association between periconceptional maternal dietary pattern and first-trimester embryonic growth.
This was a prospective cohort study of 228 women with a singleton ongoing pregnancy, of which 135 were strictly dated spontaneous pregnancies and 93 were pregnancies achieved after in-vitro fertilization or intracytoplasmatic sperm injection (IVF/ICSI). All women underwent serial transvaginal three-dimensional ultrasound (3D-US) examinations from 6 + 0 to 13 + 0 weeks' gestation. Crown-rump length (CRL) and embryonic volume (EV) measurements were performed using a virtual reality system. Information on periconceptional maternal dietary intake was collected via food frequency questionnaires. Principal component analysis was performed to identify dietary patterns. Associations between dietary patterns and CRL and EV trajectories were investigated using linear mixed models adjusted for potential confounders.
A median of five (range, one to seven) 3D-US scans per pregnancy were performed. Of 1162 datasets, quality was sufficient to perform CRL measurements in 991 (85.3%) and EV measurements in 899 (77.4%). A dietary pattern comprising high intake of fish and olive oil and a very low intake of meat was identified as beneficial for embryonic growth. In strictly dated spontaneous pregnancies, strong adherence to the 'high fish and olive oil, low meat' dietary pattern was associated with a 1.9 mm (95% CI, 0.1-3.63 mm) increase in CRL (+14.6%) at 7 weeks and a 3.4 mm (95% CI, 0.2-7.81 mm) increase (+6.9%) at 11 weeks, whereas EV increased by 0.06 cm (95% CI, 0.01-0.13 cm ) (+20.4%) at 7 weeks and 1.43 cm (95% CI, 0.99-1.87 cm ) (+14.4%) at 11 weeks. No significant association was observed in the total study population or in the IVF/ICSI subgroup.
Periconceptional maternal adherence to a high fish and olive oil, low meat dietary pattern is positively associated with embryonic growth in spontaneously conceived pregnancies. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.
探讨围孕期母体膳食模式与孕早期胚胎生长的关系。
这是一项前瞻性队列研究，纳入了 228 名单胎妊娠持续妊娠的女性，其中 135 名为严格定时的自然受孕妊娠，93 名为体外受精或卵胞浆内单精子注射（IVF/ICSI）受孕妊娠。所有女性均在妊娠 6+0 周至 13+0 周时接受经阴道三维超声（3D-US）连续检查。使用虚拟现实系统进行头臀长（CRL）和胚胎体积（EV）测量。通过食物频率问卷收集围孕期母体膳食摄入信息。采用主成分分析识别膳食模式。采用线性混合模型调整潜在混杂因素，探讨膳食模式与 CRL 和 EV 轨迹之间的关系。
中位数为每例妊娠进行五次（范围为一次至七次）3D-US 扫描。在 1162 个数据集当中，有 991 个（85.3%）数据集的 CRL 测量和 899 个（77.4%）数据集的 EV 测量质量足够。发现一种富含鱼和橄榄油、极少吃肉的膳食模式有益于胚胎生长。在严格定时的自然受孕妊娠中，强烈遵循“高鱼和橄榄油、低肉”膳食模式与妊娠 7 周时 CRL 增加 1.9mm（95%CI，0.1-3.63mm；+14.6%）和妊娠 11 周时 CRL 增加 3.4mm（95%CI，0.2-7.81mm；+6.9%）相关，而 EV 在妊娠 7 周时增加 0.06cm（95%CI，0.01-0.13cm；+20.4%）和妊娠 11 周时增加 1.43cm（95%CI，0.99-1.87cm；+14.4%）。在总研究人群或 IVF/ICSI 亚组中均未观察到显著相关性。
自然受孕妊娠的孕妇围孕期遵循高鱼和橄榄油、低肉的膳食模式与胚胎生长呈正相关。版权所有©2017 ISUOG。由 John Wiley & Sons Ltd 出版。
