Wang Jianmei, Wang Xueying, Zhu Pingan, Chen Chengmin, Wang Jianchun, Li Yan, Wang Liqiu
Energy Research Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China.
Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China.
Materials (Basel). 2019 Nov 11;12(22):3712. doi: 10.3390/ma12223712.
Monodisperse polyvinyl alcohol (PVA) microspheres have been widely used for targeted drug delivery, embolization, and templates. However, the fast and facile fabrication of PVA microspheres with uniform size and internal structure and good sphericity remains a challenge. In this study, the PVA microspheres with uniformity in the size, shape, and internal structure were rapidly fabricated, using single-emulsion droplet templates by an on-chip approach. First, we designed a polydimethylsiloxane (PDMS) microfluidic chip integrated with three functional units, used for the droplet generation, mixing of reagents, and pre-curing of PVA microspheres, respectively. Then, we precisely controlled the generation of PVA aqueous droplets, mixing of reagents, and the gelation rate for the production of high-quality microspheres by adjusting the pH value, flow rate, and the channel structure. The prepared PVA microspheres are characterized with good sphericity, uniform internal structure, and narrow size distribution. The microspheres have good adsorption capacity and recyclability for small-molecule drugs, as demonstrated by the adsorption and desorption of methylene blue (MB). The adsorption behavior is well described by the pseudo-second-order model, and intraparticle diffusion is as fast as the external film diffusion.
单分散聚乙烯醇（PVA）微球已广泛应用于靶向药物递送、栓塞和模板制备。然而，快速且简便地制备尺寸均匀、内部结构良好且球形度高的PVA微球仍然是一项挑战。在本研究中，通过片上方法使用单乳液液滴模板快速制备了尺寸、形状和内部结构均一的PVA微球。首先，我们设计了一种集成有三个功能单元的聚二甲基硅氧烷（PDMS）微流控芯片，分别用于液滴生成、试剂混合和PVA微球的预固化。然后，通过调节pH值、流速和通道结构，精确控制PVA水滴的生成、试剂混合以及凝胶化速率，以制备高质量的微球。所制备的PVA微球具有良好的球形度、均匀的内部结构和窄的尺寸分布。通过亚甲基蓝（MB）的吸附和解吸证明，这些微球对小分子药物具有良好的吸附能力和可回收性。吸附行为可用准二级模型很好地描述，颗粒内扩散与外部膜扩散一样快。
