Hubei Key Laboratory of Bioinorganic Chemistry & Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, China.
Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Nanomedicine. 2018 Nov;14(8):2551-2561. doi: 10.1016/j.nano.2018.08.003. Epub 2018 Aug 25.
It is crucial to develop dual or multi-modal self-imaging embolic microspheres to evaluate the effects of transcatheter arterial embolization therapy of tumor. However, the preparation of such hybrid microspheres always involved in multiple steps or complicated conditions. Here, poly(vinyl alcohol) (PVA) hybrid microspheres with dual-modal T/T-weighted magnetic resonance imaging (MRI) have been prepared based on microfluidic technique in one step. GdO and FeO nanoparticles with a size of ~5 nm act as T- and T-weighted MRI contrast agents, respectively, which are simultaneously in-situ synthesized in the PVA matrix via the reaction of metal ions and alkali with PVA chains as a soft template. Meanwhile, these metallic-oxide nanoparticles act as cross-linker to gelatinize the PVA droplets to obtain nano-in-micro PVA microspheres in one step. This procedure is simple, economic and feasible. The obtained nano-in-micro PVA microspheres show good magnetothermal effect, enhanced T- and T-weighted MRI and embolization effect.
开发双模态或多模态自显影栓塞微球对于评估肿瘤经导管动脉栓塞治疗的效果至关重要。然而，此类杂交微球的制备通常涉及多个步骤或复杂的条件。在这里，我们采用一步法基于微流控技术制备了具有双模态 T/T 加权磁共振成像（MRI）的聚（乙烯醇）（PVA）杂化微球。尺寸约为 5nm 的 GdO 和 FeO 纳米颗粒分别作为 T1 和 T2 加权 MRI 造影剂，通过金属离子与 PVA 链之间的反应，以 PVA 链作为软模板，原位合成于 PVA 基质中。同时，这些金属氧化物纳米颗粒作为交联剂使 PVA 液滴胶凝，一步即可得到纳米嵌入微球的 PVA 微球。该方法简单、经济、可行。所得的纳米嵌入微球的 PVA 微球显示出良好的磁热效应、增强的 T1 和 T2 加权 MRI 以及栓塞效果。
