Karol M D, Veng-Pedersen P, Brashear R E, DeAtley R E
College of Pharmacy, University of Arizona, Tucson 85721.
J Pharm Sci. 1988 Jul;77(7):571-8. doi: 10.1002/jps.2600770705.
This study was undertaken to determine if a compound which alters the bulk flow of cerebrospinal fluid (CSF) alters the elimination kinetics of a compound in the CSF. Acetazolamide was chosen as the CSF bulk flow-altering agent. It produces a relatively large effect on the flow process, affecting both choroidal and extrachoroidal CSF production, and has been shown to affect CSF flow following iv administration. The compound monitored was nicotine. Acetazolamide was administered orally for one week before and intravenously during the experiment. Nicotine was administered by a bolus injection directly into the CSF via the cisterna magna. The results indicate that the introduction of acetazolamide into the general circulation increases the rate of removal of nicotine from the CSF. Subjects receiving acetazolamide had elevated CSF pressures. The increase in CSF pressure associated with the administration of acetazolamide suggests pressure as a possible factor in the observed increase in the rate of removal of nicotine.
本研究旨在确定一种改变脑脊液（CSF）总体流量的化合物是否会改变CSF中化合物的消除动力学。选择乙酰唑胺作为改变CSF总体流量的药物。它对流动过程产生相对较大的影响，影响脉络丛和脉络丛外CSF的生成，并且已证明静脉注射后会影响CSF流动。所监测的化合物是尼古丁。在实验前一周口服乙酰唑胺，并在实验期间静脉注射。尼古丁通过经枕大池直接向CSF中推注给药。结果表明，将乙酰唑胺引入体循环会增加尼古丁从CSF中的清除率。接受乙酰唑胺的受试者CSF压力升高。与乙酰唑胺给药相关的CSF压力升高表明压力可能是观察到的尼古丁清除率增加的一个因素。
