Javaheri S
Respir Physiol. 1987 Aug;69(2):257-66. doi: 10.1016/0034-5687(87)90032-6.
The purpose of these experiments was to study the effects of acetazolamide, a carbonic anhydrase inhibitor, on cisternal cerebrospinal fluid (CSF) ions during normal acid-base balance. We measured blood and CSF acid-base variables in two groups (n = 6 in each) of anesthetized, paralyzed and mechanically ventilated dogs with bilateral ligation of renal pedicles. After baseline samples were obtained, acetazolamide was administered intravenously within 10 min (group II); group I received equal volume (20 ml) of half-normal saline. During the next 6 h, in both groups arterial blood acid-base variables and plasma strong ions remained relatively normal. In group I, mean values for cisternal CSF PCO2 were 45.3 and 49.3 mm Hg at 0 and 6 h; respective values for CSF [HCO-3] were 24.1 and 22.7 mEq/L. In group II, corresponding values for PCO2 and [HCO-3] were 46.4 and 51.9 mm Hg, and 23.8 and 23.7 mEq/L, respectively. Comparing the two groups, related mean values were not significantly different from each other. Furthermore, acetazolamide had no significant effect on CSF Na+, K+ and Cl- concentrations. Based on the results of this study and those reported previously, we conclude that under normal acid-base balance, acetazolamide does not change ionic composition of cisternal CSF, choroidal CSF or brain extracellular fluid.
这些实验的目的是研究碳酸酐酶抑制剂乙酰唑胺在正常酸碱平衡状态下对脑池脑脊液（CSF）离子的影响。我们在两组（每组n = 6）双侧肾蒂结扎的麻醉、麻痹并机械通气的犬中测量了血液和脑脊液的酸碱变量。在获取基线样本后，10分钟内静脉注射乙酰唑胺（II组）；I组接受等体积（20 ml）的半生理盐水。在接下来的6小时内，两组的动脉血酸碱变量和血浆强离子均保持相对正常。在I组中，脑池脑脊液PCO2在0小时和6小时的平均值分别为45.3和49.3 mmHg；脑脊液[HCO-3]的相应值分别为24.1和22.7 mEq/L。在II组中，PCO2和[HCO-3]的相应值分别为46.4和51.9 mmHg，以及23.8和23.7 mEq/L。比较两组，相关平均值彼此无显著差异。此外，乙酰唑胺对脑脊液Na+、K+和Cl-浓度无显著影响。基于本研究结果及先前报道的结果，我们得出结论，在正常酸碱平衡状态下，乙酰唑胺不会改变脑池脑脊液、脉络丛脑脊液或脑细胞外液的离子组成。
