Anand Pratibha, Mehler Philip S
1University of Colorado School of Medicine, Aurora, Colorado USA.
Eating Recovery Center of Denver, Denver, Colorado USA.
J Eat Disord. 2019 Nov 8;7:38. doi: 10.1186/s40337-019-0269-8. eCollection 2019.
Osteoporosis represents a common and severe complication in patients with anorexia nervosa (AN) that normally persists despite weight restoration and the resumption of regular menses. The condition may result in significant pain, injury, and disability.
We report the only published case of a complete return to normal bone density following many years of severe osteoporosis in a severely malnourished patient with AN. We describe a patient with severe and enduring AN whose osteoporosis, with resultant fractures, was completely reversed. Available patient records, imaging, and laboratory data were evaluated.
This case represents a common yet often improperly treated complication of AN. It demonstrates the potential important clinical role that targeted medicines coupled with a multifaceted supplementation and lifestyle interventions, may have for some very malnourished patients with AN. Medications, in the treatment of osteoporosis in patients with severe AN, may decrease fracture risk, enhance overall bone density, and contribute to an improved quality of life.
骨质疏松是神经性厌食症（AN）患者常见且严重的并发症，通常在体重恢复和月经恢复正常后仍会持续存在。这种情况可能导致严重疼痛、损伤和残疾。
我们报告了唯一一例已发表的病例，一名严重营养不良的AN患者在多年严重骨质疏松后骨密度完全恢复正常。我们描述了一名患有严重且持续性AN的患者，其骨质疏松及由此导致的骨折完全得到了逆转。对现有的患者记录、影像学和实验室数据进行了评估。
该病例代表了AN一种常见但治疗往往不当的并发症。它表明，对于一些严重营养不良的AN患者，靶向药物结合多方面的补充和生活方式干预可能具有重要的临床作用。在治疗严重AN患者的骨质疏松症时，药物可能会降低骨折风险，提高整体骨密度，并有助于改善生活质量。
