Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
Student Research Committee, Golestan University of Medical Science, Gorgan, Iran.
Curr Drug Targets. 2020;21(5):509-518. doi: 10.2174/1389450120666191112155654.
Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder characterized by the progressive death of dopaminergic neurons in the substantia nigra pars compacta (SNc). PD is a multifactorial disorder, with several different factors being suggested to play a synergistic pathophysiological role, including oxidative stress, autophagy, underlying pro-inflammatory events and neurotransmitters abnormalities. Overall, PD can be viewed as the product of a complex interaction of environmental factors acting on a given genetic background. The importance of this subject has gained more attention to discover novel therapies to prevent as well as treat PD. According to previous research, drugs used to treat PD have indicated significant limitations. Therefore, the role of flavonoids has been extensively studied in PD treatment. Quercetin, a plant flavonol from the flavonoid group, has been considered as a supplemental therapy for PD. Quercetin has pharmacological functions in PD by controlling different molecular pathways. Although few studies intended to evaluate the basis for the use of quercetin in the context of PD have been conducted so far, at present, there is very little evidence available addressing the underlying mechanisms of action. Various principal aspects of these treatment procedures remain unknown. Here, currently existing knowledge supporting the use of quercetin for the clinical management of PD has been reviewed.
帕金森病（PD）是一种慢性进行性神经退行性疾病，其特征是黑质致密部（SNc）中的多巴胺能神经元进行性死亡。PD 是一种多因素疾病，有几种不同的因素被认为协同发挥病理生理作用，包括氧化应激、自噬、潜在的促炎事件和神经递质异常。总的来说，PD 可以被视为环境因素在特定遗传背景下相互作用的复杂产物。因此，为了发现预防和治疗 PD 的新疗法，这一主题引起了更多的关注。根据之前的研究，用于治疗 PD 的药物显示出明显的局限性。因此，类黄酮在 PD 治疗中的作用已经得到了广泛的研究。槲皮素是类黄酮组中的一种植物类黄酮，已被认为是 PD 的一种补充疗法。槲皮素通过控制不同的分子途径在 PD 中具有药理作用。尽管迄今为止，很少有研究旨在评估在 PD 背景下使用槲皮素的基础，但目前，关于其作用机制的证据非常有限。这些治疗方法的各个主要方面仍然未知。在这里，我们回顾了目前支持使用槲皮素进行 PD 临床管理的现有知识。
