Department of Obstetrics, Tianjin Central Hospital of Obstetrics and Gynecology, Tianjin Key Laboratory of Human Development and Reproductive Regulation, Tianjin, China.
PLoS One. 2019 Nov 13;14(11):e0224739. doi: 10.1371/journal.pone.0224739. eCollection 2019.
To investigate the changes of inflammatory factors pentraxin 3 (PTX3) and hypersensitive C-reactive protein (hs-CRP) during pregnancy and their relationship with gestational diabetes mellitus (GDM).
The nested case-control study method was used. Eighty non-obese single-pregnant women diagnosed with GDM were included into the case group (GDM, n = 80), together with another eighty pregnant women with normal glucose tolerance were matched in the same period and divided into the control group (CON, n = 80), for detecting multiple biochemical indicators in different pregnancy stages by ELISA.
The serum levels of PTX3 and hs-CRP in pregnant women increased with the increase of gestational age (p < 0.001, p < 0.001). The levels of PTX3 and hs-CRP in group GDM were significantly higher in the middle and late pregnancy stages than group CON (p < 0.01, p < 0.05; p < 0.05, p < 0.05). PTX3 was positively correlated with hs-CRP, body mass index (BMI), fasting plasma glucose (FPG), and homeostasis model assessment of insulin resistance (HOMAIR).
PTX3 and hs-CRP may be related to the pathogenesis of GDM, and they are significantly increased in the second trimester, which provides a new idea for early prevention and treatment of GDM and risk prediction of long-term cardiovascular diseases.
探讨炎症因子五聚素 3（PTX3）和高敏 C 反应蛋白（hs-CRP）在妊娠期的变化及其与妊娠期糖尿病（GDM）的关系。
采用巢式病例对照研究方法，选取 80 例诊断为 GDM 的非肥胖单胎孕妇为病例组（GDM 组），同期选取 80 例血糖正常的孕妇为对照组（CON 组），采用酶联免疫吸附法检测两组孕妇不同妊娠阶段的多项生化指标。
随着妊娠周数的增加，孕妇血清 PTX3 和 hs-CRP 水平逐渐升高（p<0.001，p<0.001）。GDM 组中、晚期 PTX3 和 hs-CRP 水平明显高于 CON 组（p<0.01，p<0.05；p<0.05，p<0.05）。PTX3 与 hs-CRP、体质量指数（BMI）、空腹血糖（FPG）、稳态模型评估的胰岛素抵抗指数（HOMAIR）呈正相关。
PTX3 和 hs-CRP 可能与 GDM 的发病机制有关，且在孕中期显著升高，为 GDM 的早期预防和治疗以及长期心血管疾病风险预测提供了新的思路。
