Department of Neurology,Gansu Provincial People's Hospital, No.204, Donggang West Road, Lanzhou, 730000, Gansu, China.
School of Clinical Medicine, Gansu university of Traditional Chinese medicine, No. 35 of Dingxi East Road, Lanzhou City, Gansu Province, 730000, People's Republic of China.
BMC Neurol. 2019 Nov 13;19(1):284. doi: 10.1186/s12883-019-1500-6.
We aimed to comprehensively explore the associations between serum 25(OH)D deficiency and risk of dementia and Alzheimer's disease(AD).
We systematically searched Pubmed, the Cochrane Library, Embase and the reference lists of pertinent review articles for relevant articles published from database inception up until January 2019. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with random effects models using the Stata 12.0 statistical software package.
Twelve prospective cohort studies and four cross-sectional studies were included in this meta-analysis. The pooled HRs of dementia and AD, respectively, were 1.32 (95%CI: 1.16, 1.52) and 1.34 (95%CI: 1.13, 1.60) for vitamin D deficiency (< 20 ng/ml). In the subgroup analyses, the pooled HRs of dementia and AD, respectively, were 1.48 (95%CI: 1.19, 1.85) and 1.51 (95%CI: 1.04, 2.18) for moderate vitamin D deficiency (10-20 ng/ml) and 1.20 (95%CI: 0.99, 1.44) and 1.36 (95%CI: 1.01, 1.84) for severe vitamin D deficiency (< 10 ng/ml).
There are significant associations between vitamin D deficiency and both dementia and AD. There are stronger associations between severe vitamin D deficiency (< 10 ng/ml) and both dementia and AD compared to moderate vitamin D deficiency (10-20 ng/ml).
本研究旨在全面探讨血清 25（OH）D 缺乏与痴呆和阿尔茨海默病（AD）风险的相关性。
我们系统地检索了 Pubmed、Cochrane 图书馆、Embase 和相关综述文章的参考文献，以获取从数据库建立到 2019 年 1 月发表的相关文章。使用 Stata 12.0 统计软件包，采用随机效应模型计算合并的危险比（HR）和 95%置信区间（CI）。
本荟萃分析纳入了 12 项前瞻性队列研究和 4 项横断面研究。维生素 D 缺乏（<20ng/ml）与痴呆和 AD 的合并 HR 分别为 1.32（95%CI：1.16，1.52）和 1.34（95%CI：1.13，1.60）。在亚组分析中，维生素 D 缺乏（10-20ng/ml）与痴呆和 AD 的合并 HR 分别为 1.48（95%CI：1.19，1.85）和 1.51（95%CI：1.04，2.18），重度维生素 D 缺乏（<10ng/ml）与痴呆和 AD 的合并 HR 分别为 1.20（95%CI：0.99，1.44）和 1.36（95%CI：1.01，1.84）。
维生素 D 缺乏与痴呆和 AD 均显著相关。与中度维生素 D 缺乏（10-20ng/ml）相比，严重维生素 D 缺乏（<10ng/ml）与痴呆和 AD 的相关性更强。
