阑尾切除术后手术部位感染的全球患病率和发病率：一项系统评价和荟萃分析方案。

Global prevalence and incidence of surgical site infections after appendectomy: a systematic review and meta-analysis protocol.

作者信息

Danwang Celestin, Mazou Temgoua Ngou, Tochie Joel Noutakdie, Nzalie Rolf Nyah Tuku, Bigna Jean Joel

机构信息

Department of Surgery and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.

Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.

出版信息

BMJ Open. 2018 Aug 30;8(8):e020101. doi: 10.1136/bmjopen-2017-020101.

DOI:10.1136/bmjopen-2017-020101

PMID:30166288

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6119422/

Abstract

INTRODUCTION

Acute appendicitis is a surgical emergency and the most frequent aetiology of acute surgical abdominal pain in developed countries. Universally, its widely approved treatment is appendectomy. Like all surgical procedures, appendectomy can be associated with many complications among which are surgical site infections (SSIs).Despite the increasing number of appendectomies done around the world and the associated morbidities related to SSI after appendectomy, there is still scarcity of data concerning the global epidemiology of SSI after appendectomy. The current review aims at providing a summary of the published data on epidemiology of SSI after appendectomy.

METHODS AND DESIGN

We will include randomised controlled trials, cohort studies, case-control and cross-sectional studies. Electronic databases including Embase, MEDLINE and ISI Web of Science (Science Citation Index) will be searched for relevant abstracts of studies published between 1 January 2000 and 30 December 2017, without language restriction. The review will be reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. After screening of abstracts, study selection, data extraction and assessment of risk of bias, we shall assess the studies individually for clinical and statistical heterogeneity. Appropriate meta-analytic techniques will then be used to pool studies judged to be clinically homogenous. Visual inspection of funnel plots and Egger's test will be used to detect publication bias. Results will be presented by country and continent.

ETHICS AND DISSEMINATION

Since primary data are not collected in this study, ethical approval is not required. This review is expected to provide relevant data to help in quantifying the global burden of SSI after appendectomy. The final report will be published in a peer-reviewed journal.

TRIAL REGISTRATION NUMBER

CRD42017075257.

摘要

引言

急性阑尾炎是一种外科急症，在发达国家是急性外科腹痛最常见的病因。普遍认为，其广泛认可的治疗方法是阑尾切除术。与所有外科手术一样，阑尾切除术可能会引发许多并发症，其中包括手术部位感染（SSI）。尽管全球范围内阑尾切除术的数量不断增加，且阑尾切除术后与SSI相关的发病率也在上升，但关于阑尾切除术后SSI全球流行病学的数据仍然匮乏。本综述旨在总结已发表的关于阑尾切除术后SSI流行病学的数据。

方法与设计

我们将纳入随机对照试验、队列研究、病例对照研究和横断面研究。将检索包括Embase、MEDLINE和ISI科学网（科学引文索引）在内的电子数据库，以查找2000年1月1日至2017年12月31日期间发表的相关研究摘要，无语言限制。本综述将按照系统评价和Meta分析的首选报告项目指南进行报告。在筛选摘要、选择研究、提取数据和评估偏倚风险后，我们将分别评估各研究的临床和统计异质性。然后将使用适当的Meta分析技术汇总判断为临床同质的研究。将通过漏斗图的视觉检查和Egger检验来检测发表偏倚。结果将按国家和大洲呈现。