Danwang Celestin, Temgoua Mazou N, Agbor Valirie Ndip, Tankeu Aurel T, Noubiap Jean Jacques
Department of Surgery and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.
Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical, University of Yaoundé I, Yaoundé, Cameroon.
BMJ Open. 2017 Oct 10;7(10):e016223. doi: 10.1136/bmjopen-2017-016223.
Venous thromboembolism (VTE) is among the three major causes of cardiovascular diseases worldwide after ischaemic heart disease and stroke. Knowledge on the global epidemiology of this condition is deficient in Africa. Accurate data are needed to evaluate the burden of VTE in Africa to design effective preventive and treatment strategies. This systematic review and meta-analysis aims to summarise epidemiological data on VTE in Africa and to evaluate the use of prophylaxis in African patients at risk of VTE.
Medline, Embase, Scopus and African Journal Online will be searched for relevant abstracts of studies published between 1 January 1986 and 5 December 2016, without language restriction. After a screening of abstracts, study selection, data extraction and assessment of the risk of bias, we shall assess studies individually for clinical and statistical heterogeneity. Appropriate meta-analytic technics will then be used to pool studies judged to be clinically homogeneous. Funnel-plots analysis and Egger's test will be used to detect publication bias. Results will be presented by geographical region (Central, Eastern, Northern, Southern and Western Africa). This systematic review will be reported according to the Meta-analysis of Observational Studies in Epidemiology Guidelines.
The current study will be based on published data, and thus ethics consideration is not required. This review is expected to provide relevant data to help in quantifying the magnitude of this disease in Africa. The final report of this study will be published in a peer-reviewed journal and the findings will be submitted to relevant health authorities.
The protocol for this review has been published in the International Prospective Register of systematic reviews (http://www.crd.york.ac.uk/PROSPERO), registration number: PROSPERO CRD42017056253.
静脉血栓栓塞症（VTE）是全球范围内仅次于缺血性心脏病和中风的心血管疾病三大主要病因之一。非洲对这种疾病的全球流行病学知识匮乏。需要准确数据来评估非洲VTE的负担，以便设计有效的预防和治疗策略。本系统评价和荟萃分析旨在总结非洲VTE的流行病学数据，并评估对有VTE风险的非洲患者进行预防的应用情况。
将检索Medline、Embase、Scopus和《非洲在线期刊》，查找1986年1月1日至2016年12月5日期间发表的相关研究摘要，无语言限制。在筛选摘要、选择研究、提取数据和评估偏倚风险后，我们将分别评估研究的临床和统计异质性。然后将使用适当的荟萃分析技术汇总判断为临床同质的研究。将使用漏斗图分析和Egger检验来检测发表偏倚。结果将按地理区域（中非、东非、北非、南非和西非）呈现。本系统评价将根据流行病学观察性研究的荟萃分析指南进行报告。
本研究将基于已发表的数据，因此无需进行伦理考量。预计本综述将提供相关数据，以帮助量化非洲这种疾病的严重程度。本研究的最终报告将发表在同行评审期刊上，研究结果将提交给相关卫生当局。
本综述方案已发表在国际系统评价前瞻性注册库（http://www.crd.york.ac.uk/PROSPERO），注册号：PROSPERO CRD42017056253。
