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维生素 D 缺乏和血脂异常肥胖二态性成年人的血清神经鞘脂谱分析。

Sphingolipid serum profiling in vitamin D deficient and dyslipidemic obese dimorphic adults.

机构信息

Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.

Department of Biomedical Sciences for Health, University of Milan, Segrate-Milano, Italy.

出版信息

Sci Rep. 2019 Nov 13;9(1):16664. doi: 10.1038/s41598-019-53122-4.

DOI:10.1038/s41598-019-53122-4
PMID:31723209
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6853956/
Abstract

Recent studies on Saudi Arabians indicate a prevalence of dyslipidemia and vitamin D deficiency (25(OH)D) in both normal weight and obese subjects. In the present study the sphingolipid pattern was investigated in 23 normolipidemic normal weight (NW), 46 vitamin D deficient dyslipidemic normal weight (-vitDNW) and 60 vitamin D deficient dyslipidemic obese (-vitDO) men and women by HPTLC-primuline profiling and LC-MS analyses. Results indicate higher levels of total ceramide (Cer) and dihydroceramide (dhCers C18-22) and lower levels of total sphingomyelins (SMs) and dihydrosphingomyelin (dhSM) not only in -vitDO subjects compared to NW, but also in -vitDNW individuals. A dependency on body mass index (BMI) was observed analyzing specific Cer acyl chains levels. Lower levels of C20 and 24 were observed in men and C24.2 in women, respectively. Furthermore, LC-MS analyses display dimorphic changes in NW, -vitDNW and -vitDO subjects. In conclusion, LC-MS data identify the independency of the axis high Cers, dhCers and SMs from obesity per se. Furthermore, it indicates that long chains Cers levels are specific target of weight gain and that circulating Cer and SM levels are linked to sexual dimorphism status and can contribute to predict obese related co-morbidities in men and women.

摘要

最近对沙特阿拉伯人的研究表明，无论体重正常还是肥胖，血脂异常和维生素 D 缺乏（25(OH)D）在两者中都很普遍。在本研究中，通过 HPTLC-普里明 profiling 和 LC-MS 分析，研究了 23 名血脂正常的正常体重（NW）、46 名维生素 D 缺乏的血脂异常正常体重（-vitDNW）和 60 名维生素 D 缺乏的血脂异常肥胖（-vitDO）男女的鞘脂模式。结果表明，与 NW 相比，-vitDO 受试者的总神经酰胺（Cer）和二氢神经酰胺（dhCers C18-22）水平更高，总神经鞘磷脂（SM）和二氢神经鞘磷脂（dhSM）水平更低。通过分析特定 Cer 酰基链水平，观察到对体重指数（BMI）的依赖性。男性中 C20 和 24 的水平较低，女性中 C24.2 的水平较低。此外，LC-MS 分析显示 NW、-vitDNW 和 -vitDO 受试者存在二态性变化。总之，LC-MS 数据表明，高 Cer、dhCers 和 SMs 轴与肥胖本身无关。此外，它表明长链 Cer 水平是体重增加的特定靶点，并且循环 Cer 和 SM 水平与性别二态性状态有关，并有助于预测男性和女性肥胖相关的合并症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6520/6853956/232af76bff0b/41598_2019_53122_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6520/6853956/60c4e6f8df91/41598_2019_53122_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6520/6853956/a6fa3d49df0f/41598_2019_53122_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6520/6853956/181581fa6a4e/41598_2019_53122_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6520/6853956/232af76bff0b/41598_2019_53122_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6520/6853956/60c4e6f8df91/41598_2019_53122_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6520/6853956/a6fa3d49df0f/41598_2019_53122_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6520/6853956/181581fa6a4e/41598_2019_53122_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6520/6853956/232af76bff0b/41598_2019_53122_Fig4_HTML.jpg

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