Emotional Brain Institute, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA.
Sackler Neuroscience Graduate Program, NYU School of Medicine, New York, NY, USA.
Sci Rep. 2019 Nov 13;9(1):16701. doi: 10.1038/s41598-019-53241-y.
Sleep quality varies widely across individuals, especially during normal aging, with impaired sleep contributing to deficits in cognition and emotional regulation. Sleep can also be impacted by a variety of adverse events, including childhood adversity. Here we examined how early life adverse events impacted later life sleep structure and physiology using an animal model to test the relationship between early life adversity and sleep quality across the life span. Rat pups were exposed to an Adversity-Scarcity model from postnatal day 8-12, where insufficient bedding for nest building induces maternal maltreatment of pups. Polysomnography and sleep physiology were assessed in weaning, early adult and older adults. Early life adversity induced age-dependent disruptions in sleep and behavior, including lifelong spindle decreases and later life NREM sleep fragmentation. Given the importance of sleep in cognitive and emotional functions, these results highlight an important factor driving variation in sleep, cognition and emotion throughout the lifespan that suggest age-appropriate and trauma informed treatment of sleep problems.
睡眠质量在个体之间差异很大，尤其是在正常衰老过程中，睡眠质量下降会导致认知和情绪调节能力受损。睡眠还会受到各种不良事件的影响，包括儿童时期的逆境。在这里，我们使用动物模型研究了早期生活逆境如何影响晚年的睡眠结构和生理，以测试早期生活逆境与整个生命周期的睡眠质量之间的关系。从出生后第 8 天到 12 天，新生大鼠幼崽就会暴露在一个缺乏筑巢材料的逆境-匮乏模型中，这会导致母亲虐待幼崽。在断奶、早期成年和老年时，进行多导睡眠图和睡眠生理评估。早期生活逆境会导致睡眠和行为出现年龄依赖性的紊乱，包括终生纺锤波减少和晚年非快速眼动睡眠碎片化。考虑到睡眠在认知和情绪功能中的重要性，这些结果突出了一个重要的因素，即整个生命周期中睡眠、认知和情绪变化的驱动因素，这表明需要针对年龄和创伤进行适当的睡眠问题治疗。
