VA Portland Healthcare System, Portland, OR, USA.
Department of Neurology, Oregon Health & Science University, Portland, OR, USA.
Sci Adv. 2019 Jan 30;5(1):eaav5188. doi: 10.1126/sciadv.aav5188. eCollection 2019 Jan.
Across mammals, juveniles sleep more than adults, with rapid eye movement (REM) sleep at a lifetime maximum early in life. One function of REM sleep may be to facilitate brain development of complex behaviors. Here, we applied 1 week of early-life sleep disruption (ELSD) in prairie voles (), a highly social rodent species that forms lifelong pair bonds. Electroencephalographic recordings from juvenile voles during ELSD revealed decreased REM sleep and reduced γ power compared to baseline. ELSD impaired pair bond formation and altered object preference in adulthood. Furthermore, ELSD increased GABAergic parvalbumin immunoreactivity in the primary somatosensory cortex in adulthood, a brain region relevant to both affected behaviors. We propose that, early in life, sleep is crucial for tuning inhibitory neural circuits and the development of species-typical affiliative social behavior.
在哺乳动物中，幼年动物比成年动物睡眠更多，而快速眼动 (REM) 睡眠在生命早期达到一生的最大值。REM 睡眠的一个功能可能是促进大脑发育复杂行为。在这里，我们在草原田鼠（）中应用了一周的早期生命睡眠中断（ELSD），这是一种高度社交的啮齿动物，形成终生的配对关系。ELSD 期间幼年田鼠的脑电图记录显示，与基线相比， REM 睡眠减少，γ 功率降低。ELSD 损害了成年后的伴侣结合形成和物体偏好。此外，ELSD 增加了成年后初级体感皮层中 GABA 能神经元的 parvalbumin 免疫反应性，这是一个与受影响的行为都相关的大脑区域。我们提出，在生命早期，睡眠对于调节抑制性神经回路和发展物种特有的亲和社会行为至关重要。
