Hancerliogullari Necati, Tokmak Aytekin, Kuru Pekcan Meryem, Oksuzoglu Aysegul, Candar Tuba, Ustun Yaprak
Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, TUR.
Obsterics and Gynecology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, TUR.
Cureus. 2019 Sep 24;11(9):e5736. doi: 10.7759/cureus.5736.
Aim The main purpose of this study is the determination of serum epididymis protein 4 (HE4) levels in women diagnosed with polycystic ovary syndrome (PCOS) and comparison with non-PCOS healthy controls. Methods All consecutive women, who applied between January 2017 and June 2017 to the gynecology outpatient clinics at the Zekai Tahir Burak Women's Health Training and Research Hospital and met the study criteria, were included in this cross-sectional study. Serum human epididymis protein 4 (HE4) concentrations were measured in each woman and the mean values were compared between the PCOS and non-PCOS groups. Results A total of 90 women (45 with PCOS and 45 without PCOS) were included in the final analysis. There were no statistically significant differences between the groups in terms of age and body mass index ( >0.05). Basal serum HE4 levels were 172.8 ± 139.8 and 131.8 ± 123.1 pmol/L in the PCOS and non-PCOS groups, respectively ( = 0.415). Conclusion The serum HE4 levels were found to be similar in women with and without PCOS. No significant correlation was observed between PCOS parameters and serum HE4 levels.
目的 本研究的主要目的是测定诊断为多囊卵巢综合征（PCOS）的女性血清附睾蛋白4（HE4）水平，并与非PCOS健康对照进行比较。方法 纳入2017年1月至2017年6月期间连续到泽凯·塔希尔·布拉克妇女健康培训与研究医院妇科门诊就诊且符合研究标准的所有女性，进行这项横断面研究。测定每位女性血清人附睾蛋白4（HE4）浓度，并比较PCOS组和非PCOS组的平均值。结果 最终分析共纳入90名女性（45名PCOS患者和45名非PCOS患者）。两组在年龄和体重指数方面无统计学显著差异（>0.05）。PCOS组和非PCOS组的基础血清HE4水平分别为172.8±139.8和131.8±123.1 pmol/L（P = 0.415）。结论 发现PCOS患者和非PCOS患者的血清HE4水平相似。未观察到PCOS参数与血清HE4水平之间存在显著相关性。
