Division of Human Development, School of Clinical Sciences, University of Nottingham, Queen's Medical Centre Campus, Nottingham University Hospitals, Nottingham, United Kingdom.
Fertil Steril. 2012 Dec;98(6):1590-601.e1. doi: 10.1016/j.fertnstert.2012.08.002. Epub 2012 Sep 6.
To review and identify possible biomarkers for ovarian cancer (OC) in women with polycystic ovary syndrome (PCOS).
Systematic literature searches of MEDLINE, EMBASE, and Cochrane using the search terms "proteomics," "proteomic," and "ovarian cancer" or "ovarian carcinoma." Proteomic biomarkers for OC were then integrated with an updated previously published database of all proteomic biomarkers identified to date in patients with PCOS.
Academic department of obstetrics and gynecology in the United Kingdom.
PATIENT(S): A total of 180 women identified in the six studies.
INTERVENTION(S): Tissue samples from women with OC vs. tissue samples from women without OC.
MAIN OUTCOME MEASURE(S): Proteomic biomarkers, proteomic technique used, and methodologic quality score.
RESULT(S): A panel of six biomarkers was overexpressed both in women with OC and in women with PCOS. These biomarkers include calreticulin, fibrinogen-γ, superoxide dismutase, vimentin, malate dehydrogenase, and lamin B2.
CONCLUSION(S): These biomarkers could help improve our understanding of the links between PCOS and OC and could potentially be used to identify subgroups of women with PCOS at increased risk of OC. More studies are required to further evaluate the role these biomarkers play in women with PCOS and OC.
综述并确定多囊卵巢综合征（PCOS）女性卵巢癌（OC）的潜在生物标志物。
使用“蛋白质组学”、“蛋白质组”和“卵巢癌”或“卵巢癌”等搜索词，对 MEDLINE、EMBASE 和 Cochrane 进行系统文献检索。然后，将 OC 的蛋白质组生物标志物与迄今为止在 PCOS 患者中确定的所有蛋白质组生物标志物的更新的先前发布的数据库进行整合。
英国妇产科学术部门。
六项研究中总共 180 名女性。
OC 女性与非 OC 女性的组织样本。
蛋白质组生物标志物、使用的蛋白质组技术和方法学质量评分。
在 OC 女性和 PCOS 女性中均过度表达了一组六个生物标志物。这些生物标志物包括钙网蛋白、纤维蛋白原-γ、超氧化物歧化酶、波形蛋白、苹果酸脱氢酶和核纤层蛋白 B2。
这些生物标志物有助于提高我们对 PCOS 和 OC 之间联系的理解，并可能有助于识别 PCOS 女性中 OC 风险增加的亚组。需要更多的研究来进一步评估这些生物标志物在 PCOS 和 OC 女性中的作用。
